Gastroduodenal mucosal defense.
Gastroduodenal mucosal defense.
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DOI：
10.1097/mog.0000000000000124
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发表时间：
2014-11
影响因子：
2.5
通讯作者：
Kaunitz JD
中科院分区：
文献类型：
--
作者：
Kemmerly T;Kaunitz JD
综述胃十二指肠粘膜防御的最新进展。胃十二指肠粘膜防御领域的研究集中在持续阐明保护粘膜和影响细胞水平愈合的分子机制。回顾过去一年的文献发现，熟悉的蛋白质和介质，如一氧化氮，Toll样受体，含核苷酸结合寡聚化结构域的蛋白质，β-防御素，巨噬细胞，树突状细胞，粘蛋白，自噬，以及衰老和饮食的影响仍然是研究的主题，但也揭示了新的过程和介质，如双氧化酶，防御辐射损伤，和新的蛋白质如ZBP-89。这些新发表的研究结果有助于我们对胃十二指肠防御的全面理解，并为未来的研究和可能的新治疗靶点提供了创新途径。
To review recent developments in the field of gastroduodenal mucosal defense. Research in the field of gastroduodenal mucosal defense has focused on continued elucidation of molecular mechanisms that protect the mucosa and influence healing at the cellular level. Review of literature over the past year reveals that familiar proteins and mediators such as nitric oxide, Toll-like receptors, nucleotide-binding oligomerization domain-containing proteins, β-defensins, macrophages, dendritic cells, mucins, autophagy, and the influence of aging and diet are still subjects of study, but also brings into light new processes and mediators such as dual oxidases, defense against radiation injuries, and novel proteins such as ZBP-89. These new published findings contribute to our overall understanding of gastroduodenal defense and suggest innovative avenues of future research and possible novel therapeutic targets.