Metabolic syndrome and 10-year cardiovascular disease risk in the hoorn study
Metabolic syndrome and 10-year cardiovascular disease risk in the hoorn study
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DOI：
10.1161/circulationaha.104.516948
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发表时间：
2005-08-02
期刊：
影响因子：
37.8
通讯作者：
Heine, RJ
中科院分区：
文献类型：
--
作者：
Dekker, JM;Girman, C;Heine, RJ
背景-代谢综合征的定义有不同的说法.它们在临床环境中评估心血管疾病（CVD）风险的价值仍不清楚。我们比较了美国国家胆固醇教育计划成人治疗小组III（NCEP）、世界卫生组织（WHO）、欧洲胰岛素抵抗研究小组（EGIR）、和美国内分泌学会（ACE）关于代谢综合征的患病率和与10年致命性和非致命性CVD风险的相关性。方法和结果-Hoorn研究是一个人群-基于队列研究。本研究人群包括615名男性和749名女性，年龄在50至75岁之间，在1989至1990年基线时无糖尿病或CVD病史。基线时代谢综合征的患病率范围为17%至32%。NCEP定义与男性致命性CVD和女性非致命性CVD的年龄调整风险增加约2倍相关。对于WHO、EGIR和ACE定义，这些风险比略低。风险随着风险因素的增加而增加。胰岛素水平升高的受试者中更普遍的多个危险因素，但代谢综合征的定义，包括胰岛素水平升高没有更强的相关性risk.Conclusions -代谢综合征，但定义，与事件的心血管发病率和死亡率在欧洲人口的风险增加约2倍。在临床实践中，通过考虑个体风险因素的数量，可以获得更多信息的评估。
Background - Different definitions of the metabolic syndrome have been proposed. Their value in a clinical setting to assess cardiovascular disease (CVD) risk is still unclear. We compared the definitions proposed by the National Cholesterol Education Program Adult Treatment Panel III (NCEP), World Health Organization (WHO), European Group for the Study of Insulin Resistance (EGIR), and American College of Endocrinology (ACE) with respect to the prevalence of the metabolic syndrome and the association with 10-year risk of fatal and nonfatal CVD.Methods and Results - The Hoorn Study is a population-based cohort study. The present study population comprised 615 men and 749 women aged 50 to 75 years and without diabetes or a history of CVD at baseline in 1989 to 1990. The prevalence of the metabolic syndrome at baseline ranged from 17% to 32%. The NCEP definition was associated with about a 2-fold increase in age-adjusted risk of fatal CVD in men and nonfatal CVD in women. For the WHO, EGIR, and ACE definitions, these hazard ratios were slightly lower. Risk increased with the number of risk factors. Elevated insulin levels were more prevalent in subjects with multiple risk factors, but metabolic syndrome definitions including elevated insulin level were not more strongly associated with risk.Conclusions - The metabolic syndrome, however defined, is associated with an approximate 2-fold increased risk of incident cardiovascular morbidity and mortality in a European population. In clinical practice, a more informative assessment can be obtained by taking into account the number of individual risk factors.