Atherosclerosis basic mechanisms.
Atherosclerosis basic mechanisms.
复制标题
DOI：
10.1111/j.0954-6820.1986.tb13951.x
复制
发表时间：
2009-04
期刊：
影响因子：
--
通讯作者：
G. Bondjers;S. Olofsson;A. Fager;O. Wiklund
中科院分区：
文献类型：
--
作者：
G. Bondjers;S. Olofsson;A. Fager;O. Wiklund
Decreased coronary blood flow in ischaemic heart disease is primarily mediated by the formation of atherosclerotic lesions. Atherosclerosis may be observed in most large and medium-sized arteriesin man, withafrequency increasing with age. It may be a truism but still needs emphasizing, that the key to the pathogeneticeffectsof atherosclerosisisthe volume of the atherosclerotic lesion. The tissue mass thatrestrictsbloodflo wis composed ofthreemajor components;(i) cells;(ii) connective tissue; and (iii) lipids. A s each one of these components make a substantial contributon to the volume of the atherosclerotic lesion, it would be unrealistic to try to explain the significance of the lesion withouttakingallthree components into account. One ofthemajorproblemswit h many of the hypotheses proposed for atherogenesis has been tendencies towards one-sidedness. I n the present review, we will examine each one of the components first, then try to make a synthesis concerning what events might have lead to (i) an increased cell number;(ii) connective tissue synthesis; and (iii) lipid deposition.
