Lutetium texaphyrin (lu-tex): A potential new agent for ocular fundus angiography and photodynamic therapy
Lutetium texaphyrin (lu-tex): A potential new agent for ocular fundus angiography and photodynamic therapy
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DOI：
10.1016/s0002-9394(99)00462-6
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发表时间：
2000-03-01
影响因子：
4.2
通讯作者：
Miller, R
中科院分区：
文献类型：
--
作者：
Blumenkranz, MS;Woodburn, KW;Miller, R
目的：探讨黄体texaphyrin （lutetium texaphyrin, lutex）作为荧光显像剂在视网膜血管和脉络膜血管疾病诊断中的适用性。利用一种高效的荧光分子，也是一种光敏剂代表了一个独特的机会，以偶联诊断和治疗。方法：对正常和激光损伤的新西兰大白兔进行眼底荧光血管造影，比较lu-tex （motexafin lutetium, Optrin, Pharmacyclics Inc, Sunnyvale, California）与常规血管造影染料荧光素钠和吲啶胺绿（ICG）。血浆药代动力学数据和血浆蛋白结合评估除了视网膜光学显微镜成像和激光损伤的眼睛。结果：超声血管造影显示正常视网膜和脉络膜血管。实验诱导的脉络膜和视网膜血管病变被lu-tex增强，并表现出与荧光素或ICG不同的染色模式，特别是在病变的边缘。Lu-tex迅速从血浆中清除，39.7%与高密度脂蛋白（HDL）结合，15.8%与低密度脂蛋白（LDL）结合。结论：lutex血管造影是评价视网膜血管和脉络膜血管的一种有潜在价值的方法，与荧光素和ICG血管造影相比具有优势。可以想象，同样的药物可以用于异常血管的识别和随后的光动力治疗。(C) 2000年由爱思唯尔科学公司版权所有。
PURPOSE: To investigate the suitability of lutetium texaphyrin (lu-tex) as a fluorescence imaging agent in the delineation of retinal vascular and choroidal vascular diseases. The utilization of an efficient fluorescent molecule that is also a photosensitizer represents a unique opportunity to couple diagnosis and therapy.METHODS: Fundus fluorescence angiography comparing lu-tex (motexafin lutetium, Optrin, Pharmacyclics Inc, Sunnyvale, California) with the conventional angiographic dyes, sodium fluorescein, and indocynanine green (ICG), was performed on the eyes of normal and laser-injured New Zealand white rabbits. Plasma pharmacokinetic data and plasma protein binding were assessed in addition to light microscopy of the retina in both imaged and laser-injured eyes.RESULTS: Normal retinal and choroidal vasculature was well delineated by lu-tex angiography. Experimentally induced choroidal and retinal vascular lesions were enhanced by lu-tex and demonstrated different staining patterns than fluorescein or ICG, particularly at the margins of the lesions. Lu-tex cleared rapidly from the plasma, with 39.7% bound to the high-density lipoprotein (HDL) fraction while 15.8% was bound to the low-density lipoprotein (LDL) fraction. No evidence of retinal toxicity after dye administration was observed by either ophthalmoscopy and fundus photography or by light microscopy,CONCLUSION: Lu-tex angiography is a potentially valuable method for retinal vascular and choroidal vascular evaluation, and it has advantages over fluorescein and ICG angiography. The same agent could conceivably be used for both the identification of abnormal vasculature and subsequent photodynamic treatment. (C) 2000 by Elsevier Science Inc. All rights reserved.