Inhibitory effect of Acer tegmentosum maxim extracts on P. gingivalis LPS-induced periodontitis
Inhibitory effect of Acer tegmentosum maxim extracts on P. gingivalis LPS-induced periodontitis
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DOI：
10.1016/j.archoralbio.2019.104529
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发表时间：
2020-01-01
影响因子：
3
通讯作者：
Hyun, Kyung-Yae
中科院分区：
文献类型：
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作者：
Choi, Go-Eun;Hyun, Kyung-Yae
目的：牙周炎是一种慢性炎症，预防或治疗牙周病对于改善口腔健康和避免全身性疾病非常重要。ATM提取物传统上用于治疗各种疾病。本研究探讨了ATM提取物对缓解牙周炎在体外和vivo.Design的影响：本研究探讨是否提取物ofAcer tegmentosum Maxim（ATM）衰减牙龈卟啉单胞菌衍生的脂多糖（LPS）在体外和体内诱导的牙周炎。我们使用了实验性牙周炎的大鼠模型，其接受1 mg/kg牙龈卟啉单胞菌衍生的LPS口服给药10天。用两种不同剂量的ATM治疗牙周炎模型结果：ATM水提取物通过抗菌、抗氧化、抗炎等作用有效地改善了结扎诱导的牙周炎。这些临床前结果表明，需要进一步研究ATM在人类中的抗牙周炎作用。因此，ATM可作为一种天然的牙周炎治疗剂用于牙周炎的治疗。
Objective: Periodontitis disease is a chronic inflammation, and the prevention or treatment of periodontal disease is important for improving oral health and averting systemic diseases.Acer tegmentosum Maxim (ATM) is a type of deciduous tree in Korea. ATM extracts have been traditionally used to treat various dieases. This study investigated the effects of ATM extract on mitigation of periodontitis in vitro and in vivo.Design: The current study investigated whether extracts ofAcer tegmentosum Maxim (ATM) attenuated periodontitis induced by Porphyromonas gingivalis-derived lipopolysaccharide (LPS) in vitro and in vivo. We used a rat model of experimental periodontitis that received oral administration of 1 mg/kg P. gingivalis-derived LPS for 10 days. Periodontitis models was treated with two different dosages of ATM (30 or 100 mg/kg) during the same period of periodontal induction for histological analysis.Results: The results indicated that aqueous ATM extracts effectively ameliorated ligature-induced periodontitis through of the antibacterial, anti-oxidative, and anti-inflammatory activities.Conclusion: These pre-clinical results suggest the need for further studies on the anti-periodontitis effect of ATM in humans. Thus, ATM could be used as a natural anti-periodontitis agent for the treatment of periodontitis.