Pleiotropy of adaptive changes in populations:: comparisons among insecticide resistance genes in Culex pipiens
Pleiotropy of adaptive changes in populations:: comparisons among insecticide resistance genes in Culex pipiens
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DOI：
10.1017/s0016672397003029
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发表时间：
1997-12-01
期刊：
影响因子：
--
通讯作者：
Raymond, M
中科院分区：
文献类型：
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作者：
Chevillon, C;Bourguet, D;Raymond, M
对毒物的抗性是一个方便的模型，用于研究适应性变化是否与多效性适应性成本有关。尽管大量的文献致力于这一主题，种内比较毒物抗性基因是罕见的。我们在这里报告的结果，在同一个适应：对有机磷杀虫剂的抗性，对尖音库蚊突变体的成虫存活的多效性效应。这项研究在法国南部进行，在那里四个抗性基因相继出现，并增加频率，以响应强烈的杀虫剂控制。通过对越冬雌虫的重复取样，我们分析了三种抗性基因对成虫存活的影响。我们发现，（i）最近的基因似乎是没有不利的冬季，（ii）最古老的影响在某些环境条件下的生存，（iii）第三诱导恒定的，严重的和显性的生存成本。这种变异性进行了讨论有关的生理变化参与阻力。
Resistance to toxicants is a convenient model for investigating whether adaptive changes are associated with pleiotropic fitness costs. Despite the voluminous literature devoted to this subject, intraspecific comparisons among toxicant resistance genes are rare. We report here results on the pleiotropic effect on adult survival of Culex pipiens mutants involved in the same adaptation: the resistance to organophosphorus insecticides. This held study was performed in southern France where four resistance genes sequentially appeared and increased in frequency in response to intense insecticide control. By repeated sampling of overwintering females through winter, we analysed the impact of each of three resistance genes on adult survival. We showed that (i) the most recent gene seems to be of no disadvantage during winter, (ii) the oldest affects survival in some environmental conditions, and (iii) the third induces a constant, severe and dominant survival cost. Such variability is discussed in relation to the physiological changes involved in resistance.