Outcome devaluation by sensory-specific satiety alters Pavlovian-conditioned behavior in male and female rats.
Outcome devaluation by sensory-specific satiety alters Pavlovian-conditioned behavior in male and female rats.
复制标题
感官特异性饱腹感导致的结果贬值改变了雄性和雌性大鼠的巴甫洛夫条件行为。
DOI：
10.1101/2023.07.05.547810
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Richard,JocelynM
中科院分区：
文献类型：
--
作者：
Sood,Ankit;Richard,JocelynM
Goal-directed behavior relies on accurate mental representations of the value of expected outcomes. Disruptions to this process are a central feature of several neuropsychiatric disorders, including addiction. Goal-directed behavior is most frequently studied using instrumental paradigms paired with outcome devaluation, but cue-evoked behaviors in Pavlovian settings can also be goal-directed and therefore sensitive to changes in outcome value. Emerging literature suggests that male and female rats may differ in the degree to which their Pavlovian-conditioned responses are goal-directed, but interpretation of these findings is complicated by the tendency of female and male rats to engage in distinct types of Pavlovian responses when trained with localizable cues. Here, we used outcome devaluation via sensory-specific satiety to assess the behavioral responses in male and female Long Evans rats trained to respond to an auditory CS (conditioned stimulus) in a Pavlovian-conditioning paradigm. We found that satiety-induced devaluation led to a decrease in behavioral responding to the reward-predictive CS, with males showing an effect on both port entry latency and probability and females showing an effect only on port entry probability. Overall, our results suggest that outcome devaluation affects Pavlovian-conditioned responses in both male and female rats, but that females may be less sensitive to outcome devaluation.
