The Pco proteins are involved in periplasmic copper handling in Escherichia coli
The Pco proteins are involved in periplasmic copper handling in Escherichia coli
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DOI：
10.1016/s0006-291x(02)00726-x
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发表时间：
2002-07-19
影响因子：
3.1
通讯作者：
Brown, NL
中科院分区：
文献类型：
--
作者：
Lee, SM;Grass, G;Brown, NL
研究了大肠杆菌质粒携带的铜抗性决定因子pco与主要铜输出系统之间的相互作用，未发现直接相互作用。PcoE和PcoC蛋白是质周蛋白，PcoC与每个蛋白分子结合一个Cu离子。PcoA也是质周蛋白，可以替代染色体编码的CueO蛋白。pco决定因素被认为是通过对过量铜离子的质周处理来发挥其作用，并提高对铜离子的抗性水平，高于单独copA所赋予的水平。(C) 2002 Elsevier Science （USA）。版权所有。
The interactions between the plasmid-borne copper resistance determinant, pco, and the main copper export system in Escherichia coli have been investigated and no direct interaction has been found. The PcoE and PcoC proteins are periplasmic and PcoC binds one Cu ion per protein molecule. PcoA is also periplasmic and can substitute for the chromosomally encoded CueO protein. The pco determinant is proposed to exert its effect through periplasmic handling of excess copper ions and to increase the level of resistance to copper ions above that conferred by copA alone. (C) 2002 Elsevier Science (USA). All rights reserved.