Risk Factors for Nonadherence to Antihypertensive Treatment
Risk Factors for Nonadherence to Antihypertensive Treatment
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DOI：
10.1161/hypertensionaha.116.08729
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发表时间：
2017-06-01
期刊：
影响因子：
8.3
通讯作者：
Tomaszewski, Maciej
中科院分区：
文献类型：
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作者：
Gupta, Pankaj;Patel, Prashanth;Tomaszewski, Maciej
不坚持抗高血压治疗是导致血压控制不理想的关键因素。由于很少有研究使用客观直接的诊断方法，因此关于不依从的危险因素的数据有限且不一致。我们对来自2个欧洲国家的1348例高血压患者采用高效液相色谱-串联质谱法检测尿和血清不依从，并探讨其与主要人口统计学和治疗相关因素的关系。在英国和捷克人群中，抗高血压治疗不依从率分别为41.6%和31.5%。不遵医嘱与年龄和男性性别呈负相关。降压药数量每增加一次，不依从率分别增加85%和77% (P
Nonadherence to antihypertensive treatment is a critical contributor to suboptimal blood pressure control. There are limited and heterogeneous data on the risk factors for nonadherence because few studies used objective-direct diagnostic methods. We used high-performance liquid chromatography-tandem mass spectrometry of urine and serum to detect nonadherence and explored its association with the main demographic-and therapy-related factors in 1348 patients with hypertension from 2 European countries. The rates of nonadherence to antihypertensive treatment were 41.6% and 31.5% in the UK and Czech populations, respectively. Nonadherence was inversely related to age and male sex. Each increase in the number of antihypertensive medications led to 85% and 77% increase in nonadherence (P