Papillomavirus in cervical condylomas with and without associated cervical intraepithelial neoplasia.
Papillomavirus in cervical condylomas with and without associated cervical intraepithelial neoplasia.
复制标题
伴有或不伴有相关宫颈上皮内瘤变的宫颈尖锐湿疣中的乳头瘤病毒。
DOI：
10.1111/1523-1747.ep12522852
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Ferenczy,A
中科院分区：
文献类型：
--
作者：
Guillet,G;Braun,L;Shah,K;Ferenczy,A
本研究的目的是分析宫颈尖锐湿疣与相关宫颈上皮内瘤变（CIN）相关的细胞组织学特征，并评估病毒抗原的流行程度（通过过氧化物酶-抗过氧化物酶技术的免疫染色检测）是否随病变的组织学外观而变化。在94例组织学证实的宫颈尖锐湿疣中，几乎一半（43例）具有CIN 1级和2级的特征，对应于轻度和中度发育不良。随着相关不典型增生的特征变得更加严重，乳头瘤病毒抗原的流行率明显下降。抗原患病率在纯尖锐湿疣中为82%，在CIN 1尖锐湿疣中为32%，在CIN 2尖锐湿疣中为0%。随着病变变得更严重，病毒产生减少的证据并不能排除CIN病变的乳头瘤病毒病因。被乳头瘤病毒转化的细胞可能会停止产生病毒颗粒，即使它们继续携带病毒基因组。
The aim of this study was to analyze the cytohistologic features of cervical condylomas with respect to the presence of associated cervical intraepithelial neoplasia (CIN) and to evaluate whether or not the prevalence of virus antigen, as detected by immunologic staining with peroxidase-antiperoxidase technique, varies with the histologic appearance of the lesions. In a series of 94 histologically confirmed condylomas of the cervix, almost half (43) had features of CIN grades 1 and 2, corresponding to mild and moderate dysplasia. The prevalence of papillomavirus antigen decreased markedly as the features of associated dysplasia became more severe. The antigen prevalence was 82% in pure condylomas, 32% in condylomas with CIN 1, and 0% in condylomas with CIN 2.The evidence that virus production decreased as the lesion became more severe does not preclude papillomavirus etiology for the CIN lesions. Cells transformed by papillomaviruses may be expected to cease production of virus particles even as they continue to harbor the viral genome.