Invasive dermatophyte infection with Trichophyton interdigitale is associated with prurigo‐induced pseudoperforation and a signal transducer and activator of transcription 3 mutation
Invasive dermatophyte infection with Trichophyton interdigitale is associated with prurigo‐induced pseudoperforation and a signal transducer and activator of transcription 3 mutation
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DOI：
10.1111/bjd.15781
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发表时间：
2018-03
影响因子：
10.3
通讯作者：
J. Simpson;P. Fröbel;Suranjith L. Seneviratne;Suranjith L. Seneviratne;Michael Brown;David M. Lowe;David M. Lowe;Bodo Grimbacher;Bodo Grimbacher;M. Fliegauf;L. Fearfield
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文献类型：
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作者：
J. Simpson;P. Fröbel;Suranjith L. Seneviratne;Suranjith L. Seneviratne;Michael Brown;David M. Lowe;David M. Lowe;Bodo Grimbacher;Bodo Grimbacher;M. Fliegauf;L. Fearfield
侵袭性皮肤真菌感染，延伸到真皮以外，在免疫正常的宿主是非常罕见的。皮肤癣菌是嗜角性的，通常局限于角质层、头发和指甲。对皮肤真菌感染的易感性尚不完全清楚，但先天免疫系统关键信号通路的遗传突变已被确定。我们报告了第一例侵袭性皮肤真菌感染与突然发作的瘙痒症诱导的假手术和信号换能和转录激活子3 （STAT3）的功能缺失突变相关。
Invasive dermatophyte infection, with extension beyond the dermis, in immunocompetent hosts is exceptionally rare. Dermatophytes are keratinophilic and are usually confined to the stratum corneum, hair and nails. Susceptibility to dermatophyte infections is incompletely understood, but inherited mutations in key signalling pathways of the innate immune system have been identified. We report the first case of an invasive dermatophyte infection associated with abrupt onset of a prurigo‐induced pseudoperforation and a loss‐of‐function mutation in signal transducer and activator of transcription 3 (STAT3).