Statistical Mapping Analysis of Brain Metabolism in Patients with Subcortical Aphasia after Intracerebral Hemorrhage: A Pilot Study of F-18 FDG PET Images
Statistical Mapping Analysis of Brain Metabolism in Patients with Subcortical Aphasia after Intracerebral Hemorrhage: A Pilot Study of F-18 FDG PET Images
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DOI：
10.3349/ymj.2012.53.1.43
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发表时间：
2012-01-01
影响因子：
2.4
通讯作者：
An, Young-Sil
中科院分区：
文献类型：
--
作者：
Kim, Yong Wook;Kim, Hyoung Seop;An, Young-Sil
目的：本研究通过对F-18氟脱氧葡萄糖正电子发射断层扫描（F-18 FDG PET）图像进行统计映射分析，探讨脑出血（ICH）后皮质下失语患者的脑代谢及失语严重程度与区域脑代谢的关系。材料与方法：选取16例皮质下失语的右利手韩语患者。所有患者都进行了韩国版的西方失语电池和脑F-18 FDG PET研究。采用统计参数映射分析，我们比较了16例皮质下失语症患者和16例正常对照者的F-18 FDG PET脑代谢。此外，我们利用协方差模型研究了区域脑代谢与失语严重程度的关系。结果：与正常对照组相比，脑出血后皮层下失语症患者同侧大脑（额、顶叶、颞、枕、壳核、丘脑）和对侧小脑（P（矫正））均出现弥漫性代谢低下。
Purpose: This study was aimed to evaluate the brain metabolism in patients with subcortical aphasia after intracerebral hemorrhage (ICH) and the relationship between the severity of aphasia and regional brain metabolism, by using statistical mapping analysis of F-18 fluorodeoxyglucose positron emission tomography (F-18 FDG PET) images. Materials and Methods: Sixteen right-handed Korean speaking patients with subcortical aphasia following ICH were enrolled. All patients underwent Korean version of the Western Aphasia Battery and the brain F-18 FDG PET study. Using statistical parametric mapping analysis, we compared the brain metabolisms shown on F-18 FDG PET from 16 patients with subcortical aphasia and 16 normal controls. In addition, we investigated the relationship between regional brain metabolism and the severity of aphasia using covariance model. Results: Compared to the normal controls, subcortical aphasia after ICH showed diffuse hypometabolism in the ipsilateral cerebrum (frontal, parietal, temporal, occipital, putamen, thalamus) and in the contralateral cerebellum (P (corrected)