Diabetes-Related Cognitive Decline, a Global Health Issue, and New Treatments Approaches.
Diabetes-Related Cognitive Decline, a Global Health Issue, and New Treatments Approaches.
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DOI：
10.4018/ijphim.2017070104
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Alfaro FJ
中科院分区：
文献类型：
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作者：
Novak V;Gomez F;Dias AC;Pimentel DA;Alfaro FJ
2型糖尿病(T2 DM)的流行正在全球蔓延，并挑战健康科学在延长寿命方面取得的前所未有的成功。T2 DM与大脑加速老化、老年人功能衰退和痴呆症有关。脑胰岛素抵抗和血糖变异性是T2 DM相关脑损伤和认知功能下降的潜在机制。鼻腔胰岛素治疗已成为治疗2型糖尿病相关认知障碍的一种潜在的新疗法。可穿戴技术现在可以在几天内更好地监控行为和血糖水平，并提供实时反馈，可用于改善自我管理，并导致新的T2 DM并发症预防策略和治疗方法。
The epidemic of type 2 diabetes (T2DM) is spreading around the globe and challenging the unprecedented success of health sciences in increasing longevity. T2DM has been linked to accelerated brain aging, functional decline in older adults and dementia. Brain insulin resistance and glycemic variability are potential mechanisms underlying T2DM-related brain damage and cognitive decline. Intranasal insulin therapy has emerged as a potential new treatment for T2DM-related cognitive impairment. Wearable technologies now allow better monitoring of behaviors and glycemic levels over several days and deliver real time feedback that can be used to improve self-management and lead to new prevention strategies and therapies for T2DM complications.