Analysis of cancer risk related to longitudinal information on smoking habits.
Analysis of cancer risk related to longitudinal information on smoking habits.
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DOI：
10.1289/ehp.94102s815
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发表时间：
1994-11
影响因子：
10.4
通讯作者：
Akiba S
中科院分区：
文献类型：
--
作者：
Akiba S
辐射效应研究基金会（RERF）对由原子弹幸存者和未受辐射的受试者组成的RERF寿命研究（LSS）队列进行了40多年的跟踪。他们的生活方式，包括吸烟习惯的信息，已收集在过去的25年中，通过两个邮件调查的整个LSS队列和三个访谈调查的一个子队列的两年一度的体检计划。在本研究中，试图巩固从五个系列调查中获得的吸烟习惯的信息，然后进行风险分析，以评估更新吸烟信息对吸烟相关的肺癌风险估计的影响。通过使用从五次系列调查中获得的所有数据更新吸烟信息，吸烟相关风险的估计值变得更大，剂量反应的估计值变得更尖锐。还对肺癌以外的癌症部位进行了分析。两种方法之间的风险估计差异在其他癌症部位并不像在肺部那样明显。
Radiation Effects Research Foundation (RERF) has followed the RERF Life Span Study (LSS) cohort consisting of atomic bomb survivors and unexposed subjects for more than 40 years. The information on their lifestyles, including smoking habits, has been collected in the past 25 years through two mail surveys of the entire LSS cohort and three interview surveys of a subcohort for the biennial medical examination program. In the present study an attempt was made to consolidate the information of smoking habits obtained from the five serial surveys, and then a risk analysis was conducted to evaluate the effect of updating the smoking information on the smoking-related risk estimates for lung cancer. The estimates of smoking-related risk became larger and estimates of dose-response became sharper by updating smoking information using all of the data obtained from the five serial surveys. Analyses were also conducted for cancer sites other than lung. The differences in risk estimates between the two approaches were not as evident for the other cancer sites as for lung.