AMNESIA PRODUCED IN CATS BY LOCAL SEIZURE ACTIVITY INITIATED FROM AMYGDALA
AMNESIA PRODUCED IN CATS BY LOCAL SEIZURE ACTIVITY INITIATED FROM AMYGDALA
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DOI：
10.1016/0014-4886(68)90034-4
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发表时间：
1968-01-01
影响因子：
5.3
通讯作者：
DOTY, RW
中科院分区：
文献类型：
--
作者：
KESNER, RP;DOTY, RW
猫经过彻底的训练，可以进入一个小隔间觅食。然后，当他们在隔间里吃东西时，他们会受到令人厌恶的口腔电击。在这种刺激后24小时的测试中，所有作为对照的猫在进入隔间时都表现出很大的犹豫。当强直-阵挛性惊厥通过对整个大脑的刺激引起时，无论是单独的还是在厌恶的口震后4秒内，它们在24小时后毫不犹豫地进入隔室，因此对经历表现出完全的健忘症，并且对惊厥没有厌恶。然而，抽搐本身并不足以产生这样的失忆，因为猫受到口部电击后，由额叶皮质引起的强直性阵挛发作或中脑网状结构刺激引起的阵挛发作，与对照动物一样，它们有同样的犹豫，因此可能记住了惩罚。如果在口部电击后4秒内，通过刺激海马背侧或杏仁核引发不产生明显抽搐的电后放电，则会产生健忘症；但如果是从中隔，穹窿或腹侧海马体开始的，就不会。目前的解释是，杏仁核接近正常的功能是对厌恶经历的固定所必需的，并且癫痫活动必须充分参与杏仁核才能产生对这种经历的健忘症。
Cats were thoroughly trained to enter a small compartment for food. They then received an aversive mouth-shock while eating in the compartment. All cats used as controls showed great hesitation for entering the compartment when tested 24 hr subsequent to such a stimulus. When tonic-clonic convulsions were induced by stimulation applied across the brain, either alone or within 4 sec after an aversive mouth-shock, they unhesitantly entered the compartment 24 hr later, thus displaying full amnesia for the experience, and absence of aversiveness for the convulsion. Convulsions per se, however, are insufficient to produce such amnesia since cats subjected to mouth-shocks followed by tonic-clonic seizures initiated from the frontal cortex or clonic seizures from stimulation of the mesencephalic reticular formation had the same hesitancy as did control animals and thus presumably remembered the punishment. Amnesia was produced if, within 4 sec after the mouth-shock, electrical afterdischarges without the production of overt convulsions were initiated by stimulation of the dorsal hippocampus or amygdala; but not if initiated from the septum, fornix, or ventral hippocampus. Present interpretation is that near normal function in the amygdala is necessary for fixation of an aversive experience, and that seizure activity must engage it fully to produce amnesia for such an experience.