Insular Cortex Activity Is Associated with Effects of Negative Expectation on Nociceptive Long-Term Habituation
Insular Cortex Activity Is Associated with Effects of Negative Expectation on Nociceptive Long-Term Habituation
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DOI：
10.1523/jneurosci.2197-10.2010
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发表时间：
2010-08-25
影响因子：
5.3
通讯作者：
May, Arne
中科院分区：
文献类型：
--
作者：
Rodriguez-Raecke, Rea;Doganci, Beril;May, Arne
人们普遍认为，急性疼痛的经验是影响的背景信息塑造的期望和调节注意力，唤醒，压力和情绪。然而，很少有人知道这种影响的性质，持续时间和程度，特别是关于负面预期。我们在健康参与者中使用标准化纵向疼痛范例和疼痛热测试刺激，持续8天，随着时间的推移诱导伤害性习惯。38名健康志愿者被随机分配到两个不同的组。一组接受的信息是研究人员预计疼痛强度会随着时间的推移而增加（背景组）。另一组不提供任何信息（对照组）。所有参与者在视觉模拟量表上对每日标准化疼痛范式的疼痛强度进行评分。与先前的研究一致，对照组的疼痛评级随着时间的推移而习惯化。然而，情境组报告疼痛评分没有随时间变化。功能成像数据显示，两组之间的差异，在右侧顶骨盖。这些数据表明，消极的背景不仅对即时疼痛有影响，而且可以调节未来的疼痛感知，即使没有经验/条件反射。在神经上，这个过程是由右鳃盖区介导的。
It is generally accepted that acute painful experience is influenced by context information shaping expectation and modulating attention, arousal, stress, and mood. However, little is known about the nature, duration, and extent of this effect, particularly regarding the negative expectation. We used a standardized longitudinal pain paradigm and painful heat test stimuli in healthy participants over a time course of 8 consecutive days, inducing nociceptive habituation over time. Thirty-eight healthy volunteers were randomly assigned to two different groups. One group received the information that the investigators expected the pain intensity to increase over time (context group). The other group was not given any information (control group). All participants rated the pain intensity of the daily standardized pain paradigm on a visual analog scale. In agreement with previous studies the pain ratings in the control group habituated over time. However, the context group reported no change of pain ratings over time. Functional imaging data showed a difference between the two groups in the right parietal operculum. These data suggest that a negative context not only has an effect on immediate pain but can modulate perception of pain in the future even without experience/conditioning. Neuronally, this process is mediated by the right opercular region.