Late Onset Schizophrenia‐like Illness
Late Onset Schizophrenia‐like Illness
复制标题
迟发性精神分裂症样疾病
DOI：
10.1111/j.1532-5415.1988.tb01777.x
复制
发表时间：
1988
影响因子：
6.3
通讯作者：
Zachary Bregman
中科院分区：
文献类型：
--
作者：
T. Craig;Zachary Bregman
对658名65岁及以上临床诊断为精神分裂症的住院精神病患者的图表回顾显示，32名（4.8%）患者在45岁后出现症状，符合精神分裂症DSM - III标准（除发病年龄外）。临床病程和对治疗的反应显示，只有25%的患者明确遵循精神分裂症模式。几乎20%的患者表现出实质性的情感症状，而15.6%的患者有短暂的精神病发作，但完全缓解，40.6%的患者表现出器质性恶化的迹象。这些结果表明，不同的潜在病理过程最初可能表现为晚发性精神分裂症样疾病。入院时抑郁症状和攻击行为的出现预示着良好的治疗反应，而感觉缺陷和机体体征的发展与不良的治疗反应相关。
A chart review of 658 psychiatric inpatients aged 65 years or older with a clinical diagnosis of schizophrenia revealed 32 patients (4.8%) with onset of symptoms after aged 45 who met DSM‐III criteria for schizophrenia (except age of onset). Clinical course and response to treatment revealed only 25% to follow an unequivocally schizophrenic pattern. Almost 20% demonstrated substantial affective symptomatology, whereas 15.6% had a brief psychotic episode with full remission, and 40.6% showed signs of organic deterioration. These results suggest that diverse underlying pathologic processes may present initially as late onset schizophreniform illness. The presence of depressive symptoms and assaultive behavior on admission predicted good treatment response while sensory deficits and development of signs of organicity were associated with poor treatment response.