Fungal infection in acute leukemia
Fungal infection in acute leukemia
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急性白血病的真菌感染
DOI：
10.1002/1097-0142(197208)30:2
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发表时间：
1972
期刊：
影响因子：
6.2
通讯作者：
J. Cuttner
中科院分区：
文献类型：
--
作者：
Harold S. Mirsky;J. Cuttner
回顾性研究了65例连续死亡的急性白血病患者的尸检记录。检查每位患者的记录，寻找真菌或其他感染的证据、发烧天数、抗生素和/或抗白血病治疗的类型，以及治疗是否包括糖皮质激素。28%的患者在尸检时有严重的真菌感染。只发现腐生真菌。在任何病例中，诊断都不是在死前做出的。曲霉是最常见的入侵者；所有病例均有肺部受累。大多数发生真菌感染的患者都接受过类固醇治疗。真菌感染患者发热病程延长。真菌感染的诊断必须大力进行，包括肺活检和其他怀疑受累的器官。在对抗生素无反应的长期发烧或肺炎的选定病例中，可进行两性霉素B试验。
A retrospective study was made of the postmortem records of 65‐consecutive patients who died with acute leukemia. The records of each patient were examined for evidence of fungal or other infections, days with fever, type of antibiotic and/or antileukemic therapy, and whether treatment included the glucocorticoids. Twenty‐eight per cent of patients had severe fungal infections at autopsy. Only saprophytic fungi were found. The diagnosis was not made premortem in any of the cases. Aspergillus was the most frequent invader; pulmonary involvement was present in all cases. The majority of patients who developed fungal infections had been treated with steroids. Patients with fungal infections had prolonged febrile courses. The diagnosis of fungal infections must be pursued vigorously including biopsy of lung and other organs suspected of involvement. A trial of amphotericin B may be indicated in selected cases where prolonged fever or pneumonia unresponsive to antibiotics is present.