Reference Charts for Fetal Corpus Callosum Length A Prospective Cross-sectional Study of 2950 Fetuses
Reference Charts for Fetal Corpus Callosum Length A Prospective Cross-sectional Study of 2950 Fetuses
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DOI：
10.7863/ultra.33.6.1065
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发表时间：
2014-06-01
影响因子：
2.3
通讯作者：
Giorlandino, Claudio
中科院分区：
文献类型：
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作者：
Cignini, Pietro;Padula, Francesco;Giorlandino, Claudio
目的：本研究的目的是在方便的样本中建立胎儿胼胝体长度的参考图。方法：2008年12月至2012年1月，在艾蒿母婴医学中心进行了一项前瞻性横断面研究。在妊娠19周至37周6天的16,975个胎儿生物测量值中，有3438个(20.3%)可用。排除488项测量(14.2%)后，总共2950名胎儿(85.8%)只被考虑和分析一次。采用参数和非参数分位数回归模型进行统计分析。为了评估所建议的参考图相对于手头超声测量的不同分布假设的稳健性，我们比较了所使用的统计方法产生的特定于胎龄(GA)的参考曲线。结果：平均胼胝体长度为26.18 mm(SD，4.5 mm；95%可信区间，26.01-26.34 mm)。长度(Mm)=11.17+1.62x GA的回归方程为：长度(Mm)=11.17+1.62x GA。尺寸与妊娠的相关系数r=0.83。根据参数和非参数方法为每周孕周定义正常平均长度。结论-本工作提供了一种新的基于分位数的胼胝体长度测量参考图，可能有助于胎儿生活中的先天性痂体长异常的诊断。
Objectives-The purpose of this study was to establish reference charts for fetal corpus callosum length in a convenience sample.Methods-A prospective cross-sectional study was conducted at the Artemisia Fetal-Maternal Medical Center between December 2008 and January 2012. Among 16,975 fetal biometric measurements between 19 weeks and 37 weeks 6 days' gestation, 3438 measurements of the corpus callosum (20.3%) were available. After excluding 488 measurements (14.2%), a total of 2950 fetuses (85.8%) were considered and analyzed only once. Parametric and nonparametric quantile regression models were used for the statistical analysis. To evaluate the robustness of the proposed reference charts with respect to various distributional assumptions on the sonographic measurements at hand, we compared the gestational age (GA)-specific reference curves produced by the statistical methods used.Results-The mean corpus callosum length was 26.18 mm (SD, 4.5 mm; 95% confidence interval, 26.01-26.34 mm). The linear regression equation expressing the length of the corpus callosum as a function of GA was length (mm) = 11.17 + 1.62 x GA. The correlation between the dimension and gestation was expressed by the coefficient r = 0.83. Normal mean lengths according the parametric and nonparametric methods were defined for each week of gestation.Conclusions-This work provides new quantile-based reference charts for corpus callosum length measurements that maybe useful for diagnosis of congenital corpus callosum anomalies in fetal life.