Auto-regulation of thyroid hormone receptor genes during metamorphosis: roles in apoptosis and cell proliferation.
Auto-regulation of thyroid hormone receptor genes during metamorphosis: roles in apoptosis and cell proliferation.
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变态过程中甲状腺激素受体基因的自动调节：在细胞凋亡和细胞增殖中的作用。
DOI：
10.1387/ijdb.9551856
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
S. Damjanovski
中科院分区：
文献类型：
--
作者：
Y.;Yuan Su;Qing Li;S. Damjanovski
两栖变态是研究脊椎动物胚胎后发育的一个很好的模型系统。它涉及幼虫细胞的特定退化，通过程序性细胞死亡，具有凋亡的形态和成体细胞类型的选择性增殖和分化。甲状腺激素(T_3)在这一过程中起着重要作用，其作用可能是由T_3受体(T_3)介导的。在其他系统中的研究表明，Trs作为异源二聚体与RXRs(9-顺式维甲酸受体)形成，在有和没有T3的情况下，分别需要转录激活和抑制中的各种辅助因子存在。T3诱导的转录激活导致染色质重塑，这可能涉及到一些辅因子。最近对受体表达的研究表明，TRS在T3诱导的幼虫组织细胞凋亡和成体细胞类型的增殖中起作用。在蝌蚪和胚胎发育中的功能研究已经为这种作用提供了强有力的支持，并进一步证明了RXR在调节T3效应中的重要性。
Amphibian metamorphosis is an excellent model system for studying postembryonic development in vertebrates. It involves specific degeneration of larval cells through programmed cell death with apoptotic morphology and selective proliferation and differentiation of adult cell types. Thyroid hormone (T3) plays a causative role in this process and the effects of T3 is presumed to be mediated by T3 receptors (TRs). Studies in other systems have suggested that TRs function as heterodimers formed with RXRs (9-cis retinoic acid receptors) and require the presence of various cofactor in transcriptional activation and repression in the presence and absence of T3, respectively. The T3-induced transcriptional activation leads to chromatin remodeling which may involve some of the cofactors. Recent investigation on receptor expression has implicated a role of TRs in T3-induced apoptosis in larval tissues and proliferation of adult cell types. Functional studies in tadpoles and developing embryos have provide strong support for such a role and further demonstrate the importance of RXR in mediating the effect of T3.