HIV induces homing of resting T lymphocytes to lymph nodes.
HIV induces homing of resting T lymphocytes to lymph nodes.
复制标题
HIV 诱导静息 T 淋巴细胞归巢至淋巴结。
DOI：
10.1006/viro.1996.8397
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Cloyd,MW
中科院分区：
文献类型：
--
作者：
Wang,L;Robb,CW;Cloyd,MW
In vivoinfection with human immunodeficiency virus type 1 (HIV-1) leads to gradual depletion of CD4+ T lymphocytes from the peripheral blood and later from the lymphoid organs. The mechanism of CD4 cell depletion is not known. HIV can only replicate in dividing lymphocytes, but greater than 98% of the lymphocytesin vivoat any given time are resting and are not permissive for productive infection. We found that exposure of resting CD4+ T lymphocytes to HIV-1 transiently upregulated expression of cell surface CD62L (L-selectin), the receptor for homing to lymph nodes, with concomitant enhanced ability of these cells to bind to lymph node high endothelial venules in anex vivohoming assay (increased ∼12-fold,P< 0.001) and to home from the blood into lymph nodes following intravenous injection into SCID mice. This suggested the possibility that decreases in numbers of CD4+ T lymphocytes in the blood of HIV-1-infected subjects may reflect enhanced homing of abortively infected, resting lymphocytes into lymph nodes rather than direct virus replication in and killing of these cells, and may explain development of lymphadenopathy at a time when numbers of CD4+ T lymphocytes in the blood fall.
