Vacuum pressure generation via microfabricated converging-diverging nozzles for operation of automated pneumatic logic
Vacuum pressure generation via microfabricated converging-diverging nozzles for operation of automated pneumatic logic
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DOI：
10.1007/s10544-016-0096-5
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发表时间：
2016-08-01
影响因子：
2.8
通讯作者：
Eddington, David T.
中科院分区：
文献类型：
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作者：
Christoforidis, Theodore;Werner, Erik M.;Eddington, David T.
具有集成气动逻辑的微流体装置能够实现自动化流体处理，而无需外部控制仪器。这些芯片提供了额外的优势，它们可以由真空供电，不需要电源。这项工作描述了一种微流体会聚-发散（CD）喷嘴，该喷嘴被优化以在低输入压力下产生真空，使其适合于微流体应用，包括为集成气动逻辑提供动力。发现对于CD喷嘴收缩部（或喉部）宽度与高度的高纵横比和3.6度的发散角，产生有效的真空压力。具体地，对于42.2psia（290.8kPa）的入口压力和大约1700 sccm的体积流速，产生8.03psia（55.3kPa）的真空压力。为了证明我们的收敛-发散喷嘴装置的能力，我们将其连接到由集成气动逻辑驱动的真空动力蠕动泵，并获得从0到130 μ L/min的可调流速。最后，我们证明了一个概念系统的证明，用于电力和真空压力不容易通过为CD喷嘴提供动力与自行车轮胎泵和压力调节器。该系统能够产生足以驱动气动逻辑的稳定真空，并且可以应用于在有限资源设置中为自动化微流体提供动力。
Microfluidic devices with integrated pneumatic logic enable automated fluid handling without requiring external control instruments. These chips offer the additional advantage that they may be powered by vacuum and do not require an electricity source. This work describes a microfluidic converging-diverging (CD) nozzle optimized to generate vacuum at low input pressures, making it suitable for microfluidic applications including powering integrated pneumatic logic. It was found that efficient vacuum pressure was generated for high aspect ratios of the CD nozzle constriction (or throat) width to height and diverging angle of 3.6 degrees. In specific, for an inlet pressure of 42.2 psia (290.8 kPa) and a volumetric flow rate of approximately 1700 sccm, a vacuum pressure of 8.03 psia (55.3 kPa) was generated. To demonstrate the capabilities of our converging - diverging nozzle device, we connected it to a vacuum powered peristaltic pump driven by integrated pneumatic logic and obtained tunable flow rates from 0 to 130 mu L/min. Finally, we demonstrate a proof of concept system for use where electricity and vacuum pressure are not readily available by powering a CD nozzle with a bicycle tire pump and pressure regulator. This system is able to produce a stable vacuum sufficient to drive pneumatic logic, and could be applied to power automated microfluidics in limited resource settings.