URINARY EXCRETION + TISSUE RETENTION OF CYANOCOBALAMIN BY SUBJECTS GIVEN REPEATED PARENTERAL DOSES
URINARY EXCRETION + TISSUE RETENTION OF CYANOCOBALAMIN BY SUBJECTS GIVEN REPEATED PARENTERAL DOSES
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DOI：
10.1136/jcp.17.1.31
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发表时间：
1964-01-01
影响因子：
3.4
通讯作者：
ADAMS, JF
中科院分区：
文献类型：
--
作者：
ADAMS, JF
在30名未经治疗的维生素B12缺乏患者中，通过测量重复注射Co58维生素B12后的尿放射性，研究了注射氰钴胺的尿排泄。使用的剂量范围为54至30，000 [mu]g，每例患者每次注射时接受相同剂量。结果表明，注射量的较大或较小比例的排泄没有恒定的趋势。研究还表明，每个人和不同病人的排泄量有很大的差异，组织保留注射的氰钴胺的能力很大，保留的量往往大大超过正常的身体储存量。Co58维生素B12胃肠外感染后的放射性排泄通常在24小时内完成，但也有例外。讨论了研究结果的意义和价值。
The urinary excretion of injected cyanocobalamin was studied in 30 previously untreated vitamin B12-deficient patients by measuring the urinary radioactivity after repeated injections of Co58 vitamin B12. The dose range used was 54 to 30,000 [mu]g, each patient receiving the same dose at each injection. The results show that there is no constant trend to the excretion of greater or smaller proportions of the amount injected. It is also shown that there is a wide variation in the amounts excreted by each individual and between individual patients and that the capacity of the tissues to retain injected cyanocobalamin is very great, the amounts retained often being greatly in excess of the normal body stores. The excretion of radioactivity after parenteral infections of Co58 vitamin B12 was usually complete within 24 hours but exceptions to this were seen. The significance and value of the results is discussed.