Increased cortico-striatal connectivity during motor practice contributes to the consolidation of motor memory in writer's cramp patients
Increased cortico-striatal connectivity during motor practice contributes to the consolidation of motor memory in writer's cramp patients
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DOI：
10.1016/j.nicl.2015.04.013
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发表时间：
2015-01-01
影响因子：
4.2
通讯作者：
Lehericy, S.
中科院分区：
文献类型：
--
作者：
Gallea, C.;Balas, M.;Lehericy, S.
运动的感觉运动表征是通过重复练习在感觉运动网络中创建的，以支持成功和轻松的表现。书写痉挛（WC）是一种通过大量的手指运动练习而获得的疾病，它可能与感觉运动表征的异常获得有关。我们研究了（i）支持WC患者获得手指序列感觉运动表征的大脑网络的激活和连接变化，以及（ii）这些变化与初始练习后24小时运动表现巩固之间的联系。22例WC患者和22名年龄匹配的健康志愿者在功能性MRI记录期间练习右手（病理）的复杂序列。速度和准确性进行了测量之前和之后的做法（第1天）和24小时后的做法（第2天）。两组在第1天和第2天达到了相同的运动表现。在运动练习中，WC患者（i）海马激活和海马-纹状体功能连接减少;（ii）前运动-纹状体区过度激活，其连接与巩固后的运动表现相关。这些结果表明，WC患者使用替代网络，以达到同等性能的收购新的运动记忆。(C)2015年，作者。爱思唯尔公司出版
Sensorimotor representations of movements are created in the sensorimotor network through repeated practice to support successful and effortless performance. Writer's cramp (WC) is a disorder acquired through extensive practice of finger movements, and it is likely associated with the abnormal acquisition of sensorimotor representations. We investigated (i) the activation and connectivity changes in the brain network supporting the acquisition of sensorimotor representations of finger sequences in patients with WC and (ii) the link between these changes and consolidation of motor performance 24 h after the initial practice. Twenty-two patients with WC and 22 age-matched healthy volunteers practiced a complex sequence with the right (pathological) hand during functional MRI recording. Speed and accuracy were measured immediately before and after practice (day 1) and 24 h after practice (day 2). The two groups reached equivalent motor performance on day 1 and day 2. During motor practice, patients with WC had (i) reduced hippocampal activation and hippocampal-striatal functional connectivity; and (ii) overactivation of premotor-striatal areas, whose connectivity correlated with motor performance after consolidation. These results suggest that patients with WC use alternative networks to reach equiperformance in the acquisition of new motor memories. (C) 2015 The Authors. Published by Elsevier Inc.