MOLECULAR DISTINCTION BETWEEN FETAL AND ADULT FORMS OF MUSCLE ACETYLCHOLINE-RECEPTOR
MOLECULAR DISTINCTION BETWEEN FETAL AND ADULT FORMS OF MUSCLE ACETYLCHOLINE-RECEPTOR
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DOI：
10.1038/321406a0
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发表时间：
1986-05-22
期刊：
影响因子：
64.8
通讯作者：
SAKMANN, B
中科院分区：
文献类型：
--
作者：
MISHINA, M;TAKAI, T;SAKMANN, B
当非洲爪蟾卵母细胞注射牛α-，β-，γ-和δ-或α-，β-，γ-和ε-亚单位特异性信使RNA。这两类通道的传导性和门控特性，连同mRNA的肌肉内容物的发育变化，表明γ-通道的替代可能是一个潜在的原因。亚单位由ε-亚基负责肌肉发育期间受体的功能改变。
Distinct classes of acetylcholine receptor channels are formed when Xenopus oocytes are injected with combinations of the bovine .alpha.-, .beta.-, .gamma.- and .delta.- or the .alpha.-, .beta.-, .gamma.- and .epsilon.-subunit-specific messenger RNAs. The conductance and gating properties of the two classes of channels, in conjunction with the developmental changes in the muscular contents of the mRNAs, suggest that replacement of the .gamma.-subunit by the .epsilon.-subunit is responsible for the functional alteration of the receptor during muscle development.