Manganese-Catalyzed Asymmetric Hydrogenation of Quinolines Enabled by π-π Interaction
Manganese-Catalyzed Asymmetric Hydrogenation of Quinolines Enabled by π-π Interaction
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DOI：
10.1002/anie.202013540
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发表时间：
2021-01-15
影响因子：
16.6
通讯作者：
Liu, Qiang
中科院分区：
文献类型：
--
作者：
Liu, Chenguang;Wang, Mingyang;Liu, Qiang
报道了非贵金属催化的n-杂芳烃-喹啉的不对称加氢反应。一种新型手性钳形锰催化剂在喹啉类化合物的不对称加氢反应中表现出优异的催化活性，具有较高的产率和对映选择性（高达97% ee）。在较低的催化剂负载（S/C=4000）下，该反应的周转率达到3840，这与大多数有效的贵金属催化剂的活性相竞争。π - π相互作用保证了对映体选择性的精确调节。
The non-noble metal-catalyzed asymmetric hydrogenation of N-heteroaromatics, quinolines, is reported. A new chiral pincer manganese catalyst showed outstanding catalytic activity in the asymmetric hydrogenation of quinolines, affording high yields and enantioselectivities (up to 97 % ee). A turnover number of 3840 was reached at a low catalyst loading (S/C=4000), which is competitive with the activity of most effective noble metal catalysts for this reaction. The precise regulation of the enantioselectivity were ensured by a pi-pi interaction.