Lactobacillus casei-fermented milk improves serum and hepatic lipid profiles in diet-induced hypercholesterolaemic hamsters
Lactobacillus casei-fermented milk improves serum and hepatic lipid profiles in diet-induced hypercholesterolaemic hamsters
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干酪乳杆菌发酵乳可改善饮食诱导的高胆固醇血症仓鼠的血清和肝脂质谱
DOI：
10.1016/j.jff.2016.08.035
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发表时间：
2016-10-01
影响因子：
5.6
通讯作者：
Li, Jing-Yan
中科院分区：
文献类型：
--
作者：
Guo, Chun-Feng;Zhao, Di;Li, Jing-Yan
用高胆固醇饲料喂养仓鼠，研究了由具有胆盐水解酶活性的干酪乳杆菌F0822发酵的牛奶的降胆固醇作用。发酵乳（FM）表现出剂量依赖性的降胆固醇活性。灭菌和低剂量FM对仓鼠血脂无显著影响，而高剂量FM可显著降低血清总胆固醇（TC）、非高密度脂蛋白胆固醇（non-HDL-C）以及肝脏TC和酯化胆固醇（EC）水平。日粪总胆汁酸排泄量与血清TC、非hdl - c、肝脏TC、EC呈显著负相关。高剂量FM显著提高了日粪便总胆汁酸排泄量，这是由于菌株F0822细胞水解共轭胆汁酸和结合游离胆汁酸。这些数据表明，FM可能作为一种功能性食品，具有调节人类胆固醇代谢的潜力。(C) 2016 Elsevier Ltd.版权所有。
The hypocholesterolaemic effects of milk fermented by Lactobacillus casei F0822 with bile salt hydrolase activity were investigated in hamsters fed a cholesterol-rich diet. Fermented milk (FM) exhibited dose-dependent hypocholesterolaemic activity. Sterilized and low-dose FM did not significantly affect the lipid profile of hamsters, whereas high-dose FM significantly reduced the levels of serum total cholesterol (TC) and non-high-density lipoprotein cholesterol (non-HDL-C), as well as hepatic TC and esterified cholesterol (EC). The daily faecal total bile acid excretion was significantly negatively correlated with the serum TC and non-HDL-C, as well as with the hepatic TC and EC. High-dose FM significantly enhanced daily faecal total bile acid excretion, which attributed to the hydrolysis of conjugated bile acids and the binding of free bile acids by the cells of strain F0822. These data suggest that the FM may serve as a functional food and has the potential to regulate cholesterol metabolism in humans. (C) 2016 Elsevier Ltd. All rights reserved.