Effects of edaravone on experimental brain injury in view of free radical reaction.
Effects of edaravone on experimental brain injury in view of free radical reaction.
复制标题
从自由基反应角度观察依达拉奉对实验性脑损伤的影响。
DOI：
10.1007/978-3-7091-0651-8_67
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
S. Owada
中科院分区：
文献类型：
--
作者：
H. Nakamura;M. Uzura;K. Uchida;H. Nakayama;Y. Furuya;T. Hayashi;H. Sekino;M. Ominato;S. Owada
本研究的目的是阐明新型自由基清除剂依达拉奉对实验性脑损伤的影响。雄性 Wistar 大鼠用 1-2% 氟烷麻醉。使用受控皮质冲击损伤装置造成脑损伤。实验大鼠分为2组。在依达拉奉组中，依达拉奉（3mg/kg）静脉注射两次，每次30分钟。在盐水组中，以相同的方式施用生理盐水。依达拉奉或盐水溶液的施用使得可以通过评估自由基反应和水含量来评估依达拉奉的相对效果。结果，脑损伤后50分钟时，依达拉奉组的氧自由基水平显着低于盐水组。 180分钟时，依达拉奉组受伤大脑中的水含量显着低于盐水组。因此，我们认为依达拉奉可能对治疗头部损伤有效。
The purpose of this study is to clarify the influence of a novel free radical scavenger edaravone on experimental brain injury. Male Wistar rats were anesthetized with 1–2% halothane. Brain injury was produced using a controlled cortical impact injury device. Experimental rats were divided into 2 groups. In the edaravone group, edaravone (3 mg/kg) was twice administered intravenously for 30 minutes. In the saline group, saline solution was administered in the same way. This administration of edaravone or saline solution made it possible to evaluate the relative effects of edaravone by assessment of free radical reaction and water content. As a result, the level of oxygen free radicals at 50 minutes after brain injury was significantly lower in the edaravone group than in the saline group. The water content in the injured brain at 180 minutes was significantly lower in the edaravone group than in the saline group. Therefore, we propose that edaravone may be effective for treatment in head injury.