Modulation of inflammation by autophagy: Consequences for human disease.
Modulation of inflammation by autophagy: Consequences for human disease.
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DOI：
10.1080/15548627.2015.1071759
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发表时间：
2016
期刊：
影响因子：
13.3
通讯作者：
Netea MG
中科院分区：
文献类型：
--
作者：
Netea-Maier RT;Plantinga TS;van de Veerdonk FL;Smit JW;Netea MG
自噬和炎症是生理和病理条件下涉及的2个基本生物学过程。通过其在维持细胞内稳态中的关键作用，自噬参与调节细胞代谢、细胞存活和宿主防御。缺陷性自噬与癌症、自身免疫性疾病、神经退行性疾病和衰老等病理状况有关。炎症是抵御微生物和其他病原体的关键防线，越来越多的证据表明自噬对炎症反应的诱导和调节具有重要作用;了解这两个过程之间的平衡可能会为治疗靶向提供重要的可能性。本文综述了自噬和炎症之间的相互作用，这是一个新兴的领域，一方面对理解宿主防御具有重要意义，另一方面对免疫介导的疾病的发病机制和治疗具有重要意义。
Autophagy and inflammation are 2 fundamental biological processes involved in both physiological and pathological conditions. Through its crucial role in maintaining cellular homeostasis, autophagy is involved in modulation of cell metabolism, cell survival, and host defense. Defective autophagy is associated with pathological conditions such as cancer, autoimmune disease, neurodegenerative disease, and senescence. Inflammation represents a crucial line of defense against microorganisms and other pathogens, and there is increasing evidence that autophagy has important effects on the induction and modulation of the inflammatory reaction; understanding the balance between these 2 processes may point to important possibilities for therapeutic targeting. This review focuses on the crosstalk between autophagy and inflammation as an emerging field with major implications for understanding the host defense on the one hand, and for the pathogenesis and treatment of immune-mediated diseases on the other hand.