NIR-Light- and pH-Responsive Graphene Oxide Hybrid Cyclodextrin-Based Supramolecular Hydrogels
NIR-Light- and pH-Responsive Graphene Oxide Hybrid Cyclodextrin-Based Supramolecular Hydrogels
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近红外光和 pH 响应氧化石墨烯杂化环糊精基超分子水凝胶
DOI：
10.1021/acs.langmuir.8b03689
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发表时间：
2019
期刊：
影响因子：
3.9
通讯作者：
Wang Guojie
中科院分区：
文献类型：
--
作者：
Wang Panjun;Huang Chao;Xing Youmei;Fang Weihua;Ren Jie;Yu Haifeng;Wang Guojie
本文基于氧化石墨烯与季铵化聚合物之间的静电自组装以及α-环糊精与聚乙二醇单甲醚（mPEG）之间的主客体包合结构，构建了一种新型的三响应氧化石墨烯杂化超分子水凝胶。以ph敏感型聚（N，N-二甲氨基甲基丙烯酸乙酯）和溴端封聚乙二醇单甲醚为原料，经季铵化反应合成了季铵化聚合物。由聚乙二醇单甲醚和α-环糊精的主客体包合物制备的超分子水凝胶，当温度升高到一定温度以上时，会转变为流动溶胶相（凝胶溶胶）。氧化石墨烯片不仅作为核心材料提供额外的交联，而且还吸收近红外光并将近红外光转化为热量，从而触发凝胶-溶胶转变。所构建的氧化石墨烯杂化环糊精基超分子水凝胶对近红外光、温度和pH值有响应，有利于货物的控制释放，在递送系统领域具有很大的应用前景。
Here, a novel triple-responsive graphene oxide hybrid supramolecular hydrogel based on the electrostatic self-assembly between graphene oxide and a quaternized polymer and the host–guest inclusion between α-cyclodextrins and poly(ethylene glycol) monomethyl ether (mPEG) was constructed. The quaternized polymer was synthesized by quaternization between pH-sensitive poly(N,N-dimethylaminoethyl methacrylate) and bromine end-capped poly(ethylene glycol) monomethyl ether. The supramolecular hydrogels prepared from the host–guest inclusion of poly(ethylene glycol) monomethyl ether and α-cyclodextrins would turn into a mobile sol phase when the temperature was increased above a certain temperature (Tgel–sol). Graphene oxide sheets not only acted as a core material to provide additional cross-linking but also absorbed NIR light and converted NIR light into heat to trigger the gel–sol transition. The constructed graphene oxide hybrid cyclodextrin-based supramolecular hydrogels could respond to NIR light, temperature, and pH, which could be beneficial for controlled release of cargoes and would hold great promise in the field of delivery systems.