Microglia TREM2: A Potential Role in the Mechanism of Action of Electroacupuncture in an Alzheimer's Disease Animal Model
Microglia TREM2: A Potential Role in the Mechanism of Action of Electroacupuncture in an Alzheimer's Disease Animal Model
复制标题
小胶质细胞 TREM2：阿尔茨海默病动物模型中电针作用机制的潜在作用
DOI：
10.1155/2020/8867547
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发表时间：
2020-09-04
影响因子：
3.1
通讯作者：
Ren, Jingyu
中科院分区：
文献类型：
--
作者：
Li, Yujie;Jiang, Jing;Ren, Jingyu
阿尔茨海默病(AD)是世界面临的最严重的公共卫生问题之一。其特征是小胶质细胞活化引起的神经炎症。电针是改善阿尔茨海默病患者病情的方法之一，但其作用机制尚不清楚。髓样细胞上表达的触发受体2(TREM2)是一种小胶质细胞特异性受体，参与调节AD的神经炎症。本研究以加速衰老的易感小鼠8只为AD动物模型，采用Morris水迷宫，应用苏木精-伊红染色、免疫荧光双重染色和Western blotting等方法，探讨电针的作用及其可能的作用机制。综上所述，本研究提示电针治疗可以改善学习记忆能力(p
Alzheimer's disease (AD) is one of the most serious public health concerns facing the world. Its characteristic feature is neuroinflammation due to microglial activation. Electroacupuncture is one of the therapies employed to improve the condition of patients with AD, although its mechanism of action is still to be determined. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglia-specific receptor that is involved in regulating neuroinflammation in AD. In this study, we applied senescence-accelerated mouse-prone 8 mice as the AD animal model, used the Morris water maze, and applied hematoxylin and eosin staining, immunofluorescence double staining, and Western blotting, to explore the effects and potential mechanisms of action of electroacupuncture. In summary, this study suggested that electroacupuncture treatment could improve the learning and memory abilities (p