Endocrine determinants of incident sarcopenia in middle-aged and elderly European men
Endocrine determinants of incident sarcopenia in middle-aged and elderly European men
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DOI：
10.1002/jcsm.12030
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发表时间：
2015-09-01
影响因子：
8.9
通讯作者：
Verschueren, Sabine
中科院分区：
文献类型：
--
作者：
Gielen, Evelien;O'Neill, Terence W.;Verschueren, Sabine
背景：在男性中，低血清性类固醇、维生素D代谢产物和胰岛素样生长因子-1(IGF-1)水平对肌肉质量、肌肉力量或身体表现的长期影响尚不清楚。此外，没有数据表明这些荷尔蒙与骨质疏松症之间的关系，骨质疏松症定义为肌肉质量和功能低下。这项研究的目的是确定性激素、维生素D代谢物和IGF-1的基线水平是否可以预测肌肉质量、肌肉力量、体能和骨质疏松症的变化。方法招募518名年龄在40-79岁的男性参加欧洲男性老龄化研究，在基线水平上评估总的、游离的和生物可利用的睾酮(T)、雌二醇(E)、性激素结合球蛋白、IGF-1、25-羟基维生素D(25OHD)、1，25-二羟基维生素D(1，25(OH)(2)D)和甲状旁腺激素。在基线和平均随访4.3年后测量阑尾瘦质量(ALM)、步态速度和握力。骨量减少按Baumgartner定义(相对ALM=70岁)。
Background In men, the long-term consequences of low serum levels of sex steroids, vitamin D metabolites, and insulin-like growth factor 1 (IGF-1) on the evolution of muscle mass, muscle strength, or physical performance are unclear. Moreover, there are no data about the relationship between these hormones and incident sarcopenia defined as low muscle mass and function. The aim of this study was to determine whether the baseline levels of sex hormones, vitamin D metabolites, and IGF-1 predict changes in muscle mass, muscle strength, physical performance, and incident sarcopenia.Methods In 518 men aged 40-79 years, recruited for participation in the European Male Ageing Study, total, free, and bioavailable testosterone (T), oestradiol (E), sex hormone-binding globulin, IGF-1, 25-hydroxyvitamin D (25OHD), 1,25-dihydroxyvitamin D (1,25(OH)(2)D), and parathyroid hormone were assessed at baseline. Appendicular lean mass (aLM), gait speed, and grip strength were measured at baseline and after a mean follow-up of 4.3 years. Sarcopenia was defined by the definition of Baumgartner (relative aLM = 70years.