Hematocrit and risk of venous thromboembolism in a general population. The Tromso study
Hematocrit and risk of venous thromboembolism in a general population. The Tromso study
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DOI：
10.3324/haematol.2009.008417
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发表时间：
2010-02-01
期刊：
影响因子：
--
通讯作者：
Hansen, John-Bjarne
中科院分区：
文献类型：
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作者：
Braekkan, Sigrid K.;Mathiesen, Ellisiv B.;Hansen, John-Bjarne
红细胞压积高于正常范围的人群，如原发性或继发性红细胞增多症，易发生动脉和静脉血栓形成。设计和方法在1994-1995年参加Tromso研究的26，108名受试者中测量了红细胞压积和相关血液学变量，如血红蛋白、红细胞计数、平均红细胞体积和基线特征，随访至2007年9月1日，共发生静脉血栓栓塞事件447例。对于总人群，校正年龄、体重指数和吸烟后，总静脉血栓栓塞的多变量风险比/红细胞压积增加5%为1.25（95% CI：1.08-1.44），无端静脉血栓栓塞为1.37（95% CI：1.10-1.71）。在基于类别的分析中，红细胞压积在上20（第）百分位数的男性（男性>= 46%）总静脉血栓栓塞风险增加1.5倍（95% CI：1.08-2.21）和无端静脉血栓栓塞风险增加2.4倍（95% CI：1.36-4.15）与红细胞压积处于第40百分位数以下的男性相比。在连续和基于类别的分析中，男性的风险估计值均高于女性。血红蛋白和红细胞计数的结果是相似的红细胞压积，而平均红细胞体积是不相关的静脉thromboembolis.ConclusionsOur研究结果表明，红细胞压积和相关的血液学变量，如血红蛋白和红细胞计数是静脉血栓栓塞在一般人群中的危险因素。
BackgroundHematocrit above the normal range for the population; such as in primary or secondary erythrocytosis; predisposes to both arterial and venous thrombosis. However, little is known about the association between hematocrit and risk of venous thromboembolism in a general population.Design and MethodsHematocrit and related hematologic variables such as hemoglobin, red blood cell count, mean corpuscular volume, and baseline characteristics were measured in 26,108 subjects' who participated in the Tromso Study in 1994-1995, Incident venous thromboembolic events during follow-up were registered up to September 1(st), 2007.ResultsThere were 447 venous thromboembolic events during a median of 12.5 years of follow-up. Multivariable hazard ratios per 5% increment of hematocrit For the total population; adjusted for age, body mass index and smoking, were 1.25 (95% Cl: 1.08-1.44) for total venous thromboembolism and 1.37 (95% Cl: 1.10-1.71) for unprovoked venous thromboembolism. In category-based analyses, men with a hematocrit in the upper 20(th) percentile (>= 46% in men) had a 1.5-fold increased risk of total venous thromboembolism (95% Cl: 1.08-2.21) and a 2.4-fold increased risk of unprovoked venous thromboembolism (95% Cl: 1.36-4.15) compared to men whose hematocrit was in the lower 40(th) percentile. The risk estimates were higher for men than for women both in continuous and category-based analyses. The findings for hemoglobin and red blood cell count were similar to those for hematocrit, whereas mean corpuscular volume was not associated with venous thromboembolism.ConclusionsOur findings suggest that hematocrit and related hematologic variables such as hemoglobin and red blood cell count are risk factors for venous thromboembolism in a general population.