EFFECTS OF POSTNATAL ISOLATION REARING AND ANTIDEPRESSANT TREATMENT ON THE DENSITY OF SEROTONERGIC AND NORADRENERGIC AXONS AND DEPRESSIVE BEHAVIOR IN RATS
EFFECTS OF POSTNATAL ISOLATION REARING AND ANTIDEPRESSANT TREATMENT ON THE DENSITY OF SEROTONERGIC AND NORADRENERGIC AXONS AND DEPRESSIVE BEHAVIOR IN RATS
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DOI：
10.1016/j.neuroscience.2009.06.017
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发表时间：
2009-09-29
期刊：
影响因子：
3.3
通讯作者：
Nakamura, S.
中科院分区：
文献类型：
--
作者：
Kuramochi, M.;Nakamura, S.
在大脑发育的早期阶段，单胺能轴突的发育受到药物和环境控制的影响。此外，单胺能轴突密度的变化也被认为参与了抑郁症的病理生理过程。本实验观察了新生大鼠经抗抑郁药物治疗后，抑郁行为及含5-羟色胺或去甲肾上腺素(NA)的单胺能轴突密度的变化。在这项研究中，氯丙咪嗪(CL)被用作抗抑郁药物，因为已经积累了大量关于CL对新生儿单胺能神经元和抑郁行为的影响的数据。此外，还研究了环境条件是否能进一步改变新生儿CL治疗的效果。在目前的实验中，断奶后隔离饲养(Iso)被视为一种环境条件，因为据报道，断奶后Iso会改变大鼠大脑中5-羟色胺轴突的密度。出乎意料的是，单独接受新生儿CL治疗对5-羟色胺或NA轴突的密度或抑郁行为没有影响。断奶后群养降低杏仁中央核、基底外侧核和海马CA3区5-羟色胺轴突的密度。在内侧前额叶皮质的前缘区和下缘区以及海马齿状回，5-羟色胺轴突的密度不受社会隔离的单独影响，但在新生CL处理后被社会隔离的动物中，5-羟色胺轴突的密度减少。断奶后的Iso，而不是新生儿CL治疗，在青春期/成年早期的强迫游泳试验中增加了不动能。这些发现表明，断奶后的社会Iso改变了单胺能轴突，特别是5-羟色胺轴突的密度，并诱导了一种可能的抑郁模型，而新生儿CL单独治疗对青少年/成年期早期的NA或5-HT轴突密度或抑郁行为没有影响。(C)2009年IBRO。爱思唯尔有限公司出版。保留所有权利。
The development of monoaminergic axons is affected by pharmacological and environmental manipulations during early periods of brain development. In addition, it has been proposed that changes in the density of monoaminergic axons are involved in the pathophysiology of depression. The present experiments examined the effects of neonatal treatment with antidepressants on the density of monoaminergic axons containing 5-HT or noradrenaline (NA) and depressive behavior in rats. In this study, clomipramine (CL) was used as an antidepressant, because a large amount of data has been accumulated on the effects of neonatal CL treatment on monoaminergic neurons and depressive behavior. It was also examined whether the effects of neonatal CL treatment could be further modified by environmental conditions. In the present experiments, postweaning isolation rearing (Iso) was examined as an environmental condition, because postweaning Iso is reported to change the density of 5-HT axons in the rat brain. Unexpectedly, neonatal CL treatment alone had no effect on the density of 5-HT or NA axons or depressive behavior. Postweaning social Iso rearing reduced the density of 5-HT axons in the central nucleus and basolateral nucleus of the amygdala and CA3 of the hippocampus. In the prelimbic area and infralimbic area of medial prefrontal cortex and the dentate gyrus of the hippocampus, the density of 5-HT axons was not affected by social Iso alone, but was reduced when animals were socially isolated after neonatal CL treatment. Postweaning Iso, but not neonatal CL treatment, increased immobility in the forced swim test in adolescence/early adulthood. These findings suggest that postweaning social Iso alters the density of monoaminergic axons, particularly 5-HT axons, and induces a possible model of depression, while neonatal CL treatment alone has no effect on the density of NA or 5-HT axons or depressive behavior in adolescence/early adulthood. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.