THE HEART AND DIAPHRAGM - TARGET ORGANS IN THE NEONATAL DEATH INDUCED BY NITROFEN (2,4-DICHLOROPHENYL-PARA-NITROPHENYL ETHER)
THE HEART AND DIAPHRAGM - TARGET ORGANS IN THE NEONATAL DEATH INDUCED BY NITROFEN (2,4-DICHLOROPHENYL-PARA-NITROPHENYL ETHER)
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DOI：
10.1016/0300-483x(81)90052-4
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发表时间：
1981-01-01
期刊：
影响因子：
4.5
通讯作者：
MANSON, JM
中科院分区：
文献类型：
--
作者：
COSTLOW, RD;MANSON, JM
研究了子宫内暴露于 2,4-二氯苯基-对硝基苯醚（硝基苯醚）对新生 Long-Evans 大鼠生存能力的影响。在妊娠第 8-18 天口服这种除草剂会降低新生儿的存活率和出生体重。妊娠第 11 天是诱发新生儿死亡率最敏感的日子；这一天对母鼠的 116 mg/kg 是新生儿的 LD50。在 35 天的幸存者中观察到肾积水的发生率增加。在妊娠第 11 天暴露的动物中，这种增加与剂量相关。第 11 天暴露并在足月检查的胎儿体重减轻、骨骼骨化延迟、肾积水和膈疝发生率增加。虽然除草醚导致肾积水的发生率较高，但 4 小时新生儿的 BUN（血尿素氮）或肌酐水平并未升高。对足月胎儿心脏的详细检查发现心脏畸形，包括室间隔缺损、右心室双出口和大血管转位。心脏和膈肌是除草醚引起的新生儿死亡的靶器官。
Effects of in utero exposure to 2,4-dichlorophenyl-p-nitrophenyl ether (nitrofen) on the viability of neonatal Long-Evans rats were examined. Oral administration of this herbicide on days 8-18 of gestation reduced neonatal survival and birth weight. Day 11 of gestation was the most sensitive day for induction of neonatal mortality; 116 mg/kg to the dam on this day was the LD50 for the neonate. An increased incidence of hydronephrosis was observed in 35 day survivors. This increase was dose-related in animals exposed on day 11 of gestation. Fetuses exposed on day 11 and examined at term had reduced weights, delayed skeletal ossification and an increased frequency of hydronephrosis and diaphragmatic hernias. While nitrofen caused a high incidence of hydronephrosis, BUN [blood urea nitrogen] or creatinine levels in 4 h neonates were not elevated. Detailed examination of the hearts of term fetuses revealed cardiac malformations classified as ventricular septal defect, double outlet right ventricle and transposition of the great vessels. The heart and the diaphragm are the target organs in nitrofen-induced neonatal death.