Functional connectivity changes with concentration of sevoflurane anesthesia
Functional connectivity changes with concentration of sevoflurane anesthesia
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DOI：
10.1097/00001756-200502280-00017
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发表时间：
2005-02-28
期刊：
影响因子：
1.7
通讯作者：
Hu, XP
中科院分区：
文献类型：
--
作者：
Peltier, SJ;Kerssens, C;Hu, XP
低频振荡（< 0.08 Hz）已在功能磁共振成像研究中检测到，并且似乎在功能相关区域之间同步。麻醉剂对皮质活动的影响尚未完全确定。本研究评估了麻醉对运动皮层活动时间关系的影响。在不同麻醉状态下（使用0.0%、2.0%和1.0%稳定呼气末七氟烷）采集了6名志愿者的静息状态磁共振数据。在所有志愿者中，与清醒状态相比，轻度麻醉和深度麻醉下，功能连接图中的显著体素（p < 2.5 x 10（-5））数量分别减少了78%和98%。此外，连接图中的显著相关性在清醒状态下是双侧的，但在轻度麻醉状态下是单侧的。(c)2005年利平科特威廉姆斯&威尔金斯。
Low-frequency oscillations (< 0.08 Hz) have been detected in functional magnetic resonance imaging studies, and appear to be synchronized between functionally related areas. The effect of anesthetic agents on cortical activity is not completely characterized. This study assessed the effect of anesthesia on the temporal relations in activity in the motor cortices. Resting-state magnetic resonance data were acquired on six volunteers under different anesthetic states (using 0.0%, 2.0% and 1.0% stable end-tidal sevoflurane). Across all volunteers, the number of significant voxels (p < 2.5 x 10(-5)) in the functional connectivity maps was reduced by 78% for light anesthesia and by 98% for deep anesthesia, compared with the awake state. Additionally, significant correlations in the connectivity maps were bilateral in the awake state but unilateral in the light anesthesia state. (c) 2005 Lippincott Williams & Wilkins.