Naturally occurring Sin Nombre virus genetic reassortants
Naturally occurring Sin Nombre virus genetic reassortants
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DOI：
10.1006/viro.1995.0071
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发表时间：
1995-12-20
期刊：
影响因子：
3.7
通讯作者：
Nichol, ST
中科院分区：
文献类型：
--
作者：
Henderson, WW;Monroe, MC;Nichol, ST
基因重配已被证明在几种节段RNA病毒的进化和相关疾病的流行病学中起重要作用。Sin Nombre（SN）病毒是整个美国西部汉坦病毒肺综合征的原因。与其它汉坦病毒一样，它的基因组由S、M和L三个负义RNA片段组成。最近的分析表明，在内华达州和加州东部至少存在三种不同的汉他病毒，包括SN、前景山样病毒和El摩罗埃隆样病毒。此外，在该地区研究中心捕获的Peromyscus maniculatus啮齿动物（有时非常接近）中发现了两种不同的SN病毒谱系。通过对这些SN病毒的S、M和L基因组片段之间检测到的序列差异进行系统发育分析获得的数据与SN病毒遗传变异体之间发生的重配一致。结果表明，M（和在较小程度上S或L）基因组片段流动发生在SN病毒种群在该地区的？SN病毒与该地区存在的其他汉坦病毒类型之间未检测到重配。这一发现表明，随着遗传距离的增加，形成活抵抗体的频率降低，或者主要存在于不同啮齿动物宿主中的汉坦病毒很少有机会发生遗传相互作用。(C)出版社：Academic Press
Genetic reassortment has been shown to play an important role in the evolution of several segmented RNA viruses and in the epidemiology of associated diseases. Sin Nombre (SN) virus is the cause of hantavirus pulmonary syndrome throughout the western United States. Like other hantaviruses, it possesses a genome consisting of th ree negative-sense RNA segments, S, M, and L. Recent analysis has demonstrated the presence of at least three different hantaviruses in Nevada and eastern California, including SN, Prospect Hill-like, and El Moro Canyon-like viruses. In addition, two distinct lineages of SN virus can be found in Peromyscus maniculatus rodents (sometimes in close proximity) trapped at study sites in this region. Data obtained by phylogenetic analysis of sequence differences detected among the S, M, and L genome segments of these SN viruses are consistent with reassortment having taken place between SN virus genetic variants. The results suggest that M (and to a lesser extent S or L) genome segment flow occurs within SN virus populations in P. maniculatus in this region. No reassortment was detected between SN virus and other hantavirus types present in the area. This finding suggests that as genetic distance increases, the frequency of formation of Viable reassortants decreases, or that hantaviruses which are primarily maintained in different rodent hosts rarely have the opportunity to genetically interact. (C) 1995 Academic Press, Inc.