Functional isoforms of Pit-1 generated by alternative messenger RNA splicing.
Functional isoforms of Pit-1 generated by alternative messenger RNA splicing.
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DOI：
10.1210/mend.6.2.1569967
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发表时间：
1992-02
影响因子：
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通讯作者：
Kristin E. Konzak;David D. Moore
中科院分区：
文献类型：
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作者：
Kristin E. Konzak;David D. Moore
Pit-1是垂体特异性转录因子，激活GH和PRL基因的表达。我们已经分离出编码Pit-1的变体同种型的cDNA，我们称之为Pit-1 β。Pit-1 β在反式激活结构域中含有26个氨基酸的插入，这是由于在第一内含子末端利用了一个可选择的3 ′剪接受体。与先前描述的Pit-1 alpha一样，Pit-1 beta反式激活GH和PRL启动子。然而，较大的同种型作为更有效的GH诱导剂。
Pit-1 is a pituitary-specific transcription factor that activates expression of the GH and PRL genes. We have isolated a cDNA encoding a variant isoform of Pit-1 that we term Pit-1 beta. Pit-1 beta contains an insertion of 26 amino acids in the transactivation domain as a consequence of the utilization of an alternative 3' splice acceptor at the end of the first intron. Like the previously described Pit-1 alpha, Pit-1 beta transactivates both the GH and PRL promoters. However, the larger isoform acts as a more potent inducer of GH.