Body mass index and 25 hydroxyvitamin D status in patients with and without heart failure.
Body mass index and 25 hydroxyvitamin D status in patients with and without heart failure.
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DOI：
10.1111/j.1751-7133.2011.00270.x
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发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
Boxer R
中科院分区：
文献类型：
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作者：
DiCarlo C;Schmotzer B;Vest M;Boxer R
这项初步研究的目的是评估HF患者与健康志愿者相比，25-羟基维生素D（25[OH]D）浓度、维生素D摄入量和日光暴露之间的相关性。招募了14名50岁及以上的健康志愿者与14名HF患者进行比较。通过血清25（OH）D浓度、膳食维生素D摄入量、每周阳光暴露量和其他协变量将健康志愿者与HF患者进行比较。独立样本t检验和线性回归模型用于比较HV和HF患者之间的差异。组间平均血清25（OH）D浓度无显著差异（健康志愿者25.7±11.1 ng/ml，HF 20.4±10.2 ng/ml，p= 0.2），在任何多变量模型中均未发现组效应。BMI与血清25（OH）D浓度呈负相关（p= 0.025）。两组之间的维生素D或钙的饮食摄入量没有差异。与HF患者相比，健康志愿者的日光暴露量明显更大，但这并没有导致更高的25（OH）D。我们的研究结果表明，BMI与25（OH）D浓度有重要的关系，无论一个人是健康的还是患有HF。
The purpose of this pilot study was to assess the association between 25-hydroxyvitamin D (25[OH]D) concentrations, vitamin D intake and sunlight exposure in patients with HF compared to healthy volunteers. Fourteen healthy volunteers 50 and older were recruited to compare with 14 patients with HF. Healthy volunteers were compared to HF patients by serum 25(OH)D concentrations, dietary vitamin D intake, weekly sunlight exposure, and other covariates. Independent samples t-tests and linear regression models were used to compare differences between HV and patients with HF. The mean serum 25(OH)D concentration was not significantly different between groups (Healthy volunteers 25.7±11.1 ng/ml, HF 20.4±10.2 ng/ml, p=.2) and no group effect was found in any multivariable models. BMI regardless of group was found to be inversely associated with serum 25(OH)D concentrations (p=.025). There was no difference in the dietary intake of vitamin D or calcium between groups. The healthy volunteers had significantly greater amount of sunlight exposure but this did not result in higher 25(OH)D when compared to those with HF. Our findings suggest that BMI has an important relationship with 25(OH)D concentrations regardless of a person being healthy or having HF.