A Population-based Survey of the Prevalence and Types of Glaucoma in Nepal: The Bhaktapur Glaucoma Study
A Population-based Survey of the Prevalence and Types of Glaucoma in Nepal: The Bhaktapur Glaucoma Study
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DOI：
10.1016/j.ophtha.2011.10.021
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发表时间：
2012-04-01
期刊：
影响因子：
13.7
通讯作者：
van Rens, Ger H. M. B.
中科院分区：
文献类型：
--
作者：
Thapa, Suman S.;Paudyal, Indira;van Rens, Ger H. M. B.
目的：为了确定青光眼的患病率和类型在尼泊尔population.Design：横断面，人口为基础的survey.Participants：共4800名年龄在40岁或以上的受试者从巴克塔普尔区的加德满都valley.Methods：年龄在40岁或以上的受试者被选中使用整群抽样程序和门到门枚举的人口为基础的，横断面研究。所有受试者在基地医院接受详细的眼部检查，包括最小分辨角视力对数、屈光、压平眼压测量、前房角镜检查、透镜混浊分类系统II白内障分级、视网膜检查和瑞典交互式视力保持算法标准视野检查（如有指征）。青光眼的诊断是基于国际地理和流行病学眼科学会所描述的标准。结果：共有4003例受试者接受了全面的眼部检查（应答率83.4%），3991例受试者的完整数据可用。平均眼内压为13.3 mmHg（第97.5和99.5次眼压，分别为18和20 mmHg），平均垂直杯盘比为0.26（第97.5和99.5次眼压，分别为0.6和0.8 mmHg）。有75名受试者患有青光眼，年龄和性别标准化患病率为1.80（95%置信区间[CI]，1.68-1.92）。原发性开角型青光眼（POAG）的年龄和性别标准化患病率为1.24%（95%CI，1.14-1.34），原发性闭角型青光眼（PACG）为0.39%（95%CI，0.34-0.45），继发性青光眼为0.15%（95%CI，0.07-0.36）。青光眼患病率随年龄增长而增加，性别差异无统计学意义。原发性闭角型青光眼在女性中的发病率是男性的3倍。9只眼失明，2例受试者因青光眼而双眼失明。结论：青光眼的总患病率为1.9%。原发性开角型青光眼占68%，继发性青光眼占22.67%，继发性青光眼占9.33%。在POAG患者中，96.08%的人以前没有被诊断过。财务披露：作者对本文中讨论的任何材料没有专有或商业利益。Ophthalmology 2012;119：759-764（C）2012，美国眼科学会。
Objective: To determine the prevalence and types of glaucoma in a Nepalese population.Design: Cross-sectional, population-based survey.Participants: A total of 4800 subjects aged 40 years or older from the Bhaktapur district of Kathmandu valley.Methods: Subjects aged 40 years or older were selected using a cluster sampling procedure and door-to-door enumeration for a population-based, cross-sectional study. All subjects underwent a detailed ocular examination at the base hospital, which included logarithm of minimal angle of resolution visual acuity, refraction, applanation tonometry, gonioscopy, Lens Opacities Classification System II cataract grading, retinal examination, and Swedish Interactive Thresholding Algorithm standard perimetry when indicated.Main Outcome Measures: Diagnosis of glaucoma was based on criteria described by the International Society for Geographic and Epidemiological Ophthalmology.Results: A total of 4003 subjects underwent a comprehensive eye examination (response rate 83.4%), and complete data were available in 3991 subjects. The mean intraocular pressure was 13.3 mmHg (97.5th and 99.5th percentiles, 18 and 20 mmHg, respectively), and the mean vertical cup-to-disc ratio was 0.26 (97.5th and 99.5th percentiles, 0.6 and 0.8 mmHg, respectively). There were 75 subjects with glaucoma, an age- and sex-standardized prevalence of 1.80 (95% confidence interval [CI], 1.68-1.92). Age- and sex-standardized prevalence was 1.24% (95% CI, 1.14-1.34) for primary open-angle glaucoma (POAG), 0.39% (95% CI, 0.34-0.45) for primary angle-closure glaucoma (PACG), and 0.15% (95% CI, 0.07-0.36) for secondary glaucoma. The prevalence of glaucoma increased with an increase in age with no significant difference in gender. Primary angle-closure glaucoma was 3 times more common in women. Nine eyes were blind, and 2 subjects were bilaterally blind from glaucoma.Conclusions: The overall prevalence of glaucoma was 1.9%. Of all glaucoma cases, POAG accounted for 68%, PACG accounted for 22.67%, and secondary glaucoma accounted for 9.33%. Among the subjects with POAG, 96.08% had not been previously diagnosed.Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. Ophthalmology 2012;119:759-764 (C) 2012 by the American Academy of Ophthalmology.