Dermal IgG deposits and increase of mast cells in patients with fibromyalgia - Relevant findings or epiphenomena?
Dermal IgG deposits and increase of mast cells in patients with fibromyalgia - Relevant findings or epiphenomena?
复制标题
DOI：
10.3109/03009749709105321
复制
发表时间：
1997-01-01
影响因子：
2.1
通讯作者：
Frodin, T
中科院分区：
文献类型：
--
作者：
Enestrom, S;Bengtsson, A;Frodin, T
从25例纤维肌痛患者，5名健康对照，8例类风湿性关节炎患者，和9例局部慢性疼痛后挥鞭伤的皮肤活检，检查IgG存款和胶原类型的发生？使用直接和间接免疫荧光，对于真皮结缔组织肥大细胞，使用半薄Epon切片。纤维肌痛皮肤活检有显着较高的值IgG存款在真皮和血管壁，并表现出较高的反应性胶原蛋白III。肥大细胞的平均数量也较高，肥大细胞受损脱颗粒百分比与个体IgG免疫荧光评分之间存在相关性。这些发现支持纤维肌痛中神经源性炎症参与的假设。
Skin biopsies from 25 patients with fibromyalgia, 5 healthy controls, 8 patients with rheumatoid arthritis, and 9 patients with local chronic pain after whiplash injury, were examined for the occurrence of IgG deposits and collagen types? using direct and indirect immunofluorescence, and for dermal connective tissue mast cells, using semithin Epon sections. Fibromyalgia skin biopsies had significantly higher values of IgG deposits in the dermis and vessel walls and showed a higher reactivity for collagen III. They also had a higher mean number of mast cells, There was a correlation between the percentage of damaged degranulated mast cells and the individual IgG immunofluorescence scores. These findings support the hypothesis of neurogenic inflammation involvement in fibromyalgia.