Differential depressant effects of general anesthetics on the cardiovascular response to cocaine in mice.
Differential depressant effects of general anesthetics on the cardiovascular response to cocaine in mice.
复制标题
全身麻醉药对小鼠可卡因心血管反应的不同抑制作用。
DOI：
10.1046/j.1525-1373.1999.d01-83.x
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Morgan,JP
中科院分区：
文献类型：
--
作者：
Wang,JF;Hampton,TG;Deangelis,J;Travers,K;Morgan,JP
In recent years, murine models have gained increasing importance for studies of cardiovascular physiology and pharmacology, largely due to the development of transgenic strains with specific alterations in phenotype. Differential effects of general anesthetic agents on the cardiovascular responses to cocaine have been reported in larger mammals; therefore, we studied the effects of commonly used anesthetics on heart function and on blood pressure responses to cocaine in Swiss Webster mice. We positioned a polyethylene catheter (PE-10) in the right carotid artery or left ventricle of mice anesthetized with equivalent anesthetic dose of either keta-mine-xylazine (KX, 40 mg/kg + 5 mg/kg), pentobarbital (PEN, 40 mg/kg) or α-chloralose-urethane (CU, 80 mg/kg + 100 mg/kg). Cocaine (0.3 mg/kg, 1 mg/kg and 3 mg/kg) was administratedviathe left Jugular vein by bolus injection. In the KX group, the basal mean arterial pressure (MAP) and systolic left ventricular pressure (LVP) were 110 ± 12 and 120 ± 13 mmHg, respectively, close to conscious values. However, PEN and CU significantly decreased the basal parameters (P< 0.01 compared to the KX group). The lowest dose of cocaine (0.3 mg/kg) elicited minimal changes. Significant responses were obtained with a 1-mg/kg dose of cocaine (P< 0.01 compared to baseline). However, at 3 mg/kg, a toxic effect of cocaine appeared in all three anesthetic groups. Compared to published conscious animal data, anesthetic agents attenuated the cardiovascular effects of cocaine. Taken together, our results indicate that minimally effective doses of general anesthetics may significantly alter the basal hemodynamic state and the responses to sympathomimetic agents in the murine model, as has been reported in larger mammalian species. We concluded that anesthesia with ketamine-xylazine provides baseline hemodynamic values close to reported values in conscious animals, but also attenuates the hemodynamic response to cocaine.
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DOI：
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影响因子：
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DOI：
10.1097/00000441-198806000-00006
发表时间：
1988
期刊：
The American journal of the medical sciences
影响因子：
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DOI：
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发表时间：
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期刊：
The Journal of laboratory and clinical medicine
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Sato,K;Sato,F
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DOI：
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发表时间：
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期刊：
Endocrinology and metabolism clinics of North America (Print)
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影响因子：
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