Conformational snapshots of Tec kinases during signaling.
Conformational snapshots of Tec kinases during signaling.
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DOI：
10.1111/j.1600-065x.2008.00740.x
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发表时间：
2009-03
影响因子：
8.7
通讯作者：
Andreotti AH
中科院分区：
文献类型：
--
作者：
Joseph RE;Andreotti AH
细胞信号级联的控制对于调节免疫反应至关重要。精确的蛋白质-蛋白质相互作用和酶催化对底物的化学修饰是警告免疫细胞外来抗原存在的信号的基本组成部分。特别是，由蛋白激酶活性诱导的磷酸化事件必须通过特定的相互作用在空间和时间上进行调节，以维持正常和有效的免疫反应。许多蛋白激酶的高分辨率结构以及支持的生化数据为控制细胞信号转导的复杂调节机制提供了重要的见解。 Tec 家族激酶是免疫学上重要的激酶，其监管细节正开始出现。本综述的重点是汇集多年来获得的结构见解，以了解 Tec 激酶内以及 Tec 激酶与其他信号分子之间的域相互作用如何控制免疫细胞功能。
The control of cellular signaling cascades is of utmost importance in regulating the immune response. Exquisitely precise protein-protein interactions and chemical modification of substrates by enzymatic catalysis are the fundamental components of the signals that alert immune cells to the presence of a foreign antigen. In particular, the phosphorylation events induced by protein kinase activity must be spatially and temporally regulated by specific interactions to maintain a normal and effective immune response. High resolution structures of many protein kinases along with supporting biochemical data are providing significant insight into the intricate regulatory mechanisms responsible for controlling cellular signaling. The Tec family kinases are immunologically important kinases for which regulatory details are beginning to emerge. This review focuses on bringing together structural insights gained over the years to develop an understanding of how domain interactions both within the Tec kinases and between the Tec kinases and other signaling molecules control immune cell function.