An Oxygen Self-Evolving, Multistage Delivery System for Deeply Located Hypoxic Tumor Treatment
An Oxygen Self-Evolving, Multistage Delivery System for Deeply Located Hypoxic Tumor Treatment
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用于深部缺氧肿瘤治疗的氧气自演化多级输送系统
DOI：
10.1002/adhm.201901303
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发表时间：
2019-12-10
影响因子：
10
通讯作者：
Hu, Yong
中科院分区：
文献类型：
--
作者：
Jiang, Wei;Han, Xiaoxue;Hu, Yong
低氧诱导的放疗抵抗是肿瘤患者的一大威胁。因此，克服缺氧肿瘤微环境是一个至关重要的问题。在此，介绍了纺锤形CuS@CeO2核壳纳米粒子，其结合了自供氧、光热能力和对癌症治疗敏感的RT。CuS@CeO2核壳纳米颗粒的纺锤体形状可以增强其肿瘤渗透和随后的癌细胞内化。CeO 2的存在，作为一种纳米酶，催化肿瘤组织中的内源性H2 O2转化为O-2，将缺氧的微环境重塑为对RT敏感的微环境。包裹在CeO 2中的CuS纳米颗粒经历稳定的释放和深入的肿瘤渗透，使得受RT影响较小的病变消退。此外，体外和体内研究表明，该设计不仅减轻了RT的剂量，但更重要的是允许治疗整个肿瘤而不复发。
The hypoxia-induced resistance to radiotherapy (RT) is a great threat to cancer patients. Therefore, overcoming the hypoxia tumor microenvironment is a vital issue. Herein, spindle-shaped CuS@CeO2 core-shell nanoparticles combining self-supplied oxygen, photothermal ability, and RT sensitive to cancer therapy are introduced. The spindle shape of CuS@CeO2 core-shell nanoparticles can potentiate their tumor penetration and subsequent internalization by cancer cells. The presence of CeO2, functioning as a nanoenzyme, catalyzes the endogenous H2O2 in tumor tissue into O-2, which remodels the hypoxic microenvironment into one susceptible to RT. CuS nanoparticles encapsulated in CeO2 undergo a steady release and deep tumor penetration, allowing the regression of lesions less affected by RT. Furthermore, in vitro and in vivo studies reveal that the design not only mitigates the dosage of RT, but more importantly allows the entire tumor to be treated without relapses.