Natural Killer Cell-Based Immunotherapy in Gynecologic Malignancy: A Review.
Natural Killer Cell-Based Immunotherapy in Gynecologic Malignancy: A Review.
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DOI：
10.3389/fimmu.2017.01825
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发表时间：
2017
影响因子：
7.3
通讯作者：
Geller MA
中科院分区：
文献类型：
--
作者：
Uppendahl LD;Dahl CM;Miller JS;Felices M;Geller MA
利用免疫系统已被证明是治疗恶性肿瘤的有效疗法。自从发现自然杀伤（NK）细胞以来，旨在操纵和增强其抗癌效应功能的策略一直是深入研究的主题。NK细胞免疫生物学的最新进展导致了有前途的治疗方法的发展。本文就NK细胞免疫生物学的最新进展以及NK细胞免疫治疗在卵巢癌、宫颈癌和子宫癌中的临床应用作一综述。
Harnessing the immune system has proven an effective therapy in treating malignancies. Since the discovery of natural killer (NK) cells, strategies aimed to manipulate and augment their effector function against cancer have been the subject of intense research. Recent progress in the immunobiology of NK cells has led to the development of promising therapeutic approaches. In this review, we will focus on the recent advances in NK cell immunobiology and the clinical application of NK cell immunotherapy in ovarian, cervical, and uterine cancer.