Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer's disease through reducing neuroinflammation and modulating intestinal microbiota.
Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer's disease through reducing neuroinflammation and modulating intestinal microbiota.
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富氢水通过减少神经炎症和调节肠道微生物群来改善阿尔茨海默病小鼠模型的神经病理损伤。
DOI：
10.4103/1673-5374.317992
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发表时间：
2022-03
影响因子：
6.1
通讯作者：
Du XB
中科院分区：
文献类型：
--
作者：
Lin YT;Shi QQ;Zhang L;Yue CP;He ZJ;Li XX;He QJ;Liu Q;Du XB
氢显示出治疗阿尔茨海默病的潜力。立体定向注射以前曾被用作一种有创的活性氢给药方法，但这种方法在临床实践中有局限性。在这项研究中，三重转基因（3×Tg）阿尔茨海默病小鼠用富氢水处理7个月。结果表明，富氢水可防止3×Tg阿尔茨海默病小鼠的突触丢失和神经元死亡，抑制老年斑，并减少过度磷酸化的tau蛋白和神经元缠结。此外，富氢水改善了大脑能量代谢紊乱和肠道植物群失衡，减少了炎症反应。这些发现表明，富氢水是一种有效的氢供体，可以治疗阿尔茨海默病。本研究于2014年6月15日获得中国深圳大学动物伦理与福利委员会批准（批准号AEWC-20140615-002）。
Hydrogen exhibits the potential to treat Alzheimer's disease. Stereotactic injection has been previously used as an invasive method of administering active hydrogen, but this method has limitations in clinical practice. In this study, triple transgenic (3×Tg) Alzheimer's disease mice were treated with hydrogen-rich water for 7 months. The results showed that hydrogen-rich water prevented synaptic loss and neuronal death, inhibited senile plaques, and reduced hyperphosphorylated tau and neurofibrillary tangles in 3×Tg Alzheimer's disease mice. In addition, hydrogen-rich water improved brain energy metabolism disorders and intestinal flora imbalances and reduced inflammatory reactions. These findings suggest that hydrogen-rich water is an effective hydrogen donor that can treat Alzheimer's disease. This study was approved by the Animal Ethics and Welfare Committee of Shenzhen University, China (approval No. AEWC-20140615-002) on June 15, 2014.