Purinergic cotransmission.
Purinergic cotransmission.
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DOI：
10.3410/b1-46
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发表时间：
2009-06-09
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影响因子：
--
通讯作者：
Burnstock G
中科院分区：
文献类型：
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作者：
Burnstock G
在周围神经系统和中枢神经系统的大多数神经中，ATP与经典递质是一种共递质，但在不同的物种和组织以及不同的发育、生理和病理生理条件下，其比例有所不同。ATP与去甲肾上腺素和神经肽Y一起从交感神经释放。它与乙酰胆碱作为一种共递质从供应膀胱的副交感神经释放，形成骨骼神经肌肉连接点和大脑中的一些神经元。它也与一氧化氮和非肾上腺素能抑制性肠神经的血管活性肠多肽，与初级传入感觉神经和下丘脑的谷氨酸，以及与中枢神经系统某些神经元的多巴胺和5-羟色胺一起释放。共传递提供了神经传递和神经调节机制的微妙的局部变化。
ATP is a cotransmitter with classical transmitters in most nerves in the peripheral nervous system and central nervous system, although the proportions vary between species and tissues and in different developmental, physiological and pathophysiological conditions. ATP is released together with noradrenaline and neuropeptide Y from sympathetic nerves. It is released as a cotransmitter with acetylcholine from parasympathetic nerves supplying the bladder, developing skeletal neuromuscular junctions and some neurons in the brain. It is also released with nitric oxide and vasoactive intestinal polypeptide from non-adrenergic inhibitory enteric nerves, with glutamate from primary afferent sensory nerves and in the hypothalamus, and with dopamine and 5-hydroxytryptamine from some neurons in the central nervous system. Cotransmission offers subtle, local variations in neurotransmission and neuromodulation mechanisms.