Noninvasive imaging of cardiac transmembrane potentials within three-dimensional myocardium by means of a realistic geometry anisotropic heart model
Noninvasive imaging of cardiac transmembrane potentials within three-dimensional myocardium by means of a realistic geometry anisotropic heart model
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DOI：
10.1109/tbme.2003.817637
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发表时间：
2003-10-01
影响因子：
4.6
通讯作者：
Zhang, X
中科院分区：
文献类型：
--
作者：
He, B;Li, GL;Zhang, X
我们开发了一种新的方法，通过各向异性心脏模型在三维(3-D)心肌内成像心脏跨膜电位(TMPs)。通过最小化测量的体表电位图(BSPM)和心脏模型生成的BSPM的目标函数，从体表心电图估计心脏TMP的分布。计算机模拟研究已经被用来评估目前使用起搏协议的三维TMP成像方法。模拟了24个部位的单部位起搏和12对房室环附近的双部位起搏。模拟结果表明，当BSPM中加入10-V高斯白噪声(GWN)时，单部位起搏的真分布与反向估计的TMP分布之间的相关系数(CC)和相对误差(RE)分别为0.9915+/-0.0041和0.1266+/-0.0326，而双部位起搏的相关系数(CC)和相对误差(RE)分别为0.9889+/-0.0034和0.1473+/-0.0237。心脏和躯干的几何不确定度也通过将心脏位置移动10 mm和躯干大小改变10%来评估。当考虑这些几何不确定性时，“真实”的TMP分布和反向估计的TMP分布之间的CC>0.97。本文的模拟结果证明了从体表心电测量中无创估计TMP在整个心室中分布的可行性，并表明本方法可能成为三维心肌内分布式心脏电生理过程的无创成像的一种有用的替代方法。
We have developed a new approach for imaging cardiac transmembrane potentials (TMPs) within the three-dimensional (3-D) myocardium by means of an anisotropic heart model. The cardiac TMP distribution is estimated from body surface electrocardiograms by minimizing objective functions of the "measured" body surface potential maps (BSPMs) and the heart-model-generated BSPMs. Computer simulation studies have been conducted to evaluate the present 3-D TMP imaging approach using pacing protocols. Simulations of single-site pacing at 24 sites throughout the ventricles, as well as dual-site pacing at 12 pairs of sites in the vicinity of atrio-ventricular ring were performed. The present simulation results show that the correlation coefficient (CC) and relative error (RE) between the "true" and inversely estimated TMP distributions were 0.9915 +/- 0.0041 and 0.1266 +/- 0.0326, for single-site pacing, and 0.9889 +/- 0.0034 and 0.1473 +/- 0.0237 for dual-site pacing, respectively, when 10 muV Gaussian white noise (GWN) was added to the BSPMs. The effects of heart and torso geometry uncertainty were also evaluated by shifting the heart position by 10 mm and altering the torso size by 10%. The CC between the "true" and inversely estimated TMP distributions was above 0.97 when these geometry uncertainties were considered. The present simulation results demonstrate the feasibility of noninvasive estimation of TMP distribution throughout the ventricles from body surface electrocardiographic measurements, and suggest that the present method may become a useful alternative in noninvasive imaging of distributed cardiac electrophysiological processes within the 3-D myocardium.