Oxidative damage to lipids is rapidly reduced during migratory stopovers
Oxidative damage to lipids is rapidly reduced during migratory stopovers
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DOI：
10.1111/1365-2435.13540
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发表时间：
2020-02-18
影响因子：
5.2
通讯作者：
Isaksson, Caroline
中科院分区：
文献类型：
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作者：
Eikenaar, Cas;Winslott, Erica;Isaksson, Caroline
大多数迁徙的鸟类需要在飞行之间停留以补充燃料。最近，中途停留的其他目的也被提出，包括从代谢要求很高的迁徙飞行中恢复生理功能。一个明显不可避免的，但有害的生理效应的迁徙飞行是增加脂质和蛋白质的氧化损伤。我们在这里，首次，测试是否迁徙鸟类能够减少他们的氧化损伤在中途停留。为了能够收集大量鸟类个体的纵向数据，我们暂时将野生北方麦穗鸟关在笼子里，这是一种长距离的迁徙鸟，在迁徙过程中关在笼子里不会受到压力。在中途停留的第一天和第三天的中午左右，对鸟类进行血液采样，以确定丙二醛（MDA）浓度，这是一种常用的脂质氧化损伤的标志物，我们发现，MDA浓度在中途停留期间显着下降，校正底物的过氧化能力时，结果不变。减少的程度是无关的食物消耗量或燃料的积累。我们的研究结果支持的假设，中途停留服务减少氧化损伤，避免重新思考鸟类如何完成他们的迁移。他们还强调需要将生理恢复作为迁移（时间）组织的驱动力。可以在本文的支持信息中找到免费的简明语言摘要。
Most migrating birds need to stopover in between flights in order to refuel. Lately, additional purposes of stopover have been suggested, including physiological recovery from metabolically demanding migratory flight. One apparently unavoidable, but harmful physiological effect of migratory flight is increased oxidative damage to lipids and proteins.We here, for the first time, tested whether migrating birds are able to reduce their oxidative damage during stopover. To be able to collect longitudinal data on a large number of individual birds, we temporarily caged wild northern wheatears, a long-distance migrant which does not suffer stress when caged during migration. Around noon on the first and third day at stopover, the birds were blood-sampled to determine malondialdehyde (MDA) concentration, a commonly used marker of oxidative damage to lipids.We found that MDA concentrations significantly decreased during stopover, a result unchanged when correcting for the peroxidizability of the substrate. The extent of the decrease was unrelated to the amounts of food consumed or of fuel accumulated.Our findings support the hypothesis that stopovers serve reduction of oxidative damage, warranting re-thinking of how birds accomplish their migrations. They also highlight the need to include physiological recovery as a driver of the (temporal) organization of migration.A free Plain Language Summary can be found within the Supporting Information of this article.