Inflammatory Bowel Disease Does Not Impact Mortality but Increases Length of Hospitalization in Patients with Acute Myocardial Infarction.
Inflammatory Bowel Disease Does Not Impact Mortality but Increases Length of Hospitalization in Patients with Acute Myocardial Infarction.
复制标题
炎症性肠病不会影响死亡率，但会增加急性心肌梗死患者的住院时间。
DOI：
10.1007/s10620-020-06818-x
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发表时间：
2021
影响因子：
3.1
通讯作者：
Dave,Maneesh
中科院分区：
文献类型：
--
作者：
Sinh,Preetika;Tabibian,JamesH;Biyani,PrachiS;Mehta,Kathan;Mansoor,Emad;LoftusJr,EdwardV;Dave,Maneesh
摘要 背景和目的 炎症性肠病 (IBD) 与心血管事件风险增加相关。我们的目的是调查 IBD 患者心肌梗死 (MI) 的结果。方法 我们利用 1998 年至 2010 年全国住院患者样本的数据进行了一项横断面研究。ICD-9-CM 代码用于识别患有克罗恩病 (CD)(555.X)、溃疡性结肠炎 (UC)(556.X) 和急性 MI (410.X) 的患者。比较伴有和不伴有 IBD 的 MI 患者的结果。进行单变量分析。在调整混杂因素后，使用多变量逻辑回归来确定 UC 和 CD 对院内 MI 死亡率的影响。结果 总共分析了 2,629,161 名 MI、3,607 名 UC 和 3784 名 CD 患者。 UC（优势比 OR，1.12；95% CI 0.98–1.29）和 CD（OR 0.99；95% CI 0.86–1.15）不影响 MI 患者的院内死亡率。伴有或不伴有 UC 的 MI 患者（7.75% 与 7.05%；p=0.25）或伴有或不伴有 CD 的 MI 患者（6.50% 与 6.59%；p=0.87）的院内死亡率没有差异。与非 IBD 患者相比，IBD 患者的住院时间 (LOS) 更长，UC 患者的总费用也更高（65,182 比 53,542；p < 0.001）。结论 本研究表明 IBD 不会影响 MI 导致的院内死亡率。然而，患有 IBD 的 MI 患者的 LOS 较长。 UC 患者的总住院费用高于没有 IBD 的 MI 患者。需要进一步的前瞻性研究来评估 IBD 患者的 MI 结局。
Abstract Background and Aim Inflammatory bowel diseases (IBD) have been associated with increased risk of cardiovascular events. We aimed to investigate the outcomes of myocardial infarction (MI) in patients with IBD. Methods We performed a cross-sectional study utilizing data from the Nationwide Inpatient Sample from the years 1998 to 2010. ICD-9-CM codes were used to identify patients with Crohn’s disease (CD)(555. X), ulcerative colitis (UC)(556. X), and acute MI (410. X). Outcomes in patients with MI with and without IBD were compared. Univariate analysis was performed. Multivariate logistic regression was used to determine the effect of UC and CD on in-hospital MI mortality after adjusting for confounders. Results A total of 2,629,161 MI, 3,607 UC and 3784 CD patients were analyzed. UC (odds ratio OR, 1.12; 95% CI 0.98–1.29) and CD (OR 0.99; 95% CI 0.86–1.15) did not affect in-hospital mortality in patients with MI. There was no difference between in-hospital mortality in patients with MI with or without UC (7.75% vs. 7.05%; p= 0.25) or in patients with MI with or without CD (6.50% vs. 6.59%; p= 0.87). The length of stay (LOS) was higher in IBD patients and total charges were statistically higher in patients with UC as compared to non-IBD patients (65,182vs. 53,542; p< 0.001). Conclusions This study shows that IBD does not impact in-hospital mortality from MI. However, patients with MI with IBD have longer LOS. Patients with UC have higher total hospitalization charges than patients with MI without IBD. Further prospective studies are needed to assess the outcomes of MI in IBD patients.